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Machine translation
1. (WO2006124431) SYSTEMS AND METHODS OF BLOOD-BASED THERAPIES HAVING A MICROFLUIDIC MEMBRANELESS EXCHANGE DEVICE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/124431    International Application No.:    PCT/US2006/018008
Publication Date: 23.11.2006 International Filing Date: 09.05.2006
IPC:
A61M 37/00 (2006.01)
Applicants: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK [US/US]; 412 Low Memorial Library, 535 West 116th Street, New York, NY 10027 (US) (For All Designated States Except US).
LEONARD, Edward, F. [US/US]; (US) (For US Only).
WEST, Alan, C. [US/US]; (US) (For US Only).
SHAPLEY, Nina, C. [US/US]; (US) (For US Only).
TANG, Zhongliang [CN/US]; (US) (For US Only)
Inventors: LEONARD, Edward, F.; (US).
WEST, Alan, C.; (US).
SHAPLEY, Nina, C.; (US).
TANG, Zhongliang; (US)
Agent: LAUB, David; PROSKAUER ROSE LLP, 1001 Pennsylvania Avenue NW, Suite 400 South, Washington, DC 20004-2533 (US)
Priority Data:
11/127,905 12.05.2005 US
Title (EN) SYSTEMS AND METHODS OF BLOOD-BASED THERAPIES HAVING A MICROFLUIDIC MEMBRANELESS EXCHANGE DEVICE
(FR) SYSTEMES ET METHODES THERAPEUTIQUES SANGUINES CONSISTANT A UTILISER UN DISPOSITIF D'ECHANGE MICROFLUIDIQUE SANS MEMBRANE
Abstract: front page image
(EN)The present invention is directed to devices, systems and methods for removing undesirable materials from a sample fluid by contact with a second fluid. The sample fluid flows as a thin layer adjacent to, or between, concurrently flowing layers of the second fluid, without an intervening membrane. In various embodiments, a secondary separator is used to restrict the removal of desirable substances and effect the removal of undesirable substances from blood. The invention is useful in a variety of situations where a sample fluid is to be purified via a diffusion mechanism against an extractor fluid. Moreover, the invention may be used for the removal of components from a sample fluid that vary in size. When blood is the sample fluid, for example, this may include the removal of 'small' molecules, 'middle' molecules, macromolecules, macromolecular aggregates, and cells, from the blood sample to the extractor fluid.
(FR)La présente invention concerne des dispositifs, des systèmes et des procédés permettant d'éliminer des matériaux indésirables d'un échantillon de fluide par contact avec un second fluide. L'échantillon de fluide s'écoule en une couche fine de manière adjacente à, ou entre, des couches du second fluide s'écoulant de manière simultanée, sans utiliser de membrane. Dans divers modes de réalisation, un séparateur secondaire est utilisé pour restreindre l'élimination des substances indésirables, et procéder à l'élimination des substances indésirables du sang. L'invention est utilisée dans diverses situations dans lesquelles un échantillon de fluide doit être purifié par un mécanisme de diffusion contre un fluide d'extraction. L'invention peut, de plus, être utilisée pour éliminer les composants d'un échantillon de fluide de dimension variable. Lorsque l'échantillon de fluide est du sang, par exemple, le procédé consiste à éliminer les 'petites' molécules, les molécules 'moyennes', les macromolécules, les agrégats macromoléculaires, et des cellules de l'échantillon de sang par le fluide d'extraction.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)