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1. (WO2006124062) METHOD FOR FOSTERING BONE FORMATION AND PRESERVATION
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2006/124062 International Application No.: PCT/US2005/040032
Publication Date: 23.11.2006 International Filing Date: 07.11.2005
Chapter 2 Demand Filed: 22.11.2006
IPC:
A61K 38/17 (2006.01) ,A61K 38/12 (2006.01) ,A61K 31/665 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17
from animals; from humans
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
04
Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
12
Cyclic peptides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
66
Phosphorus compounds
665
having oxygen as a ring hetero atom, e.g. fosfomycin
Applicants:
UNIGENE LABORATORIES, INC. [US/US]; 110 Little Falls Road Fairfield, New Jersey 07004, US (AllExceptUS)
YALE UNIVERSITY [US/US]; 2 Whitney Avenue New Haven, Connecticut 06511, US (AllExceptUS)
VIGNERY, Agnes [US/US]; US (UsOnly)
MEHTA, Nozer M. [US/US]; US (UsOnly)
GILLIGAN, James P. [US/US]; US (UsOnly)
Inventors:
VIGNERY, Agnes; US
MEHTA, Nozer M.; US
GILLIGAN, James P.; US
Agent:
WEINER, Samuel H. ; Ostrolenk, Faber, Gerb & Soffen, LLP 1180 Avenue Of The Americas New York, New York 10036, US
Priority Data:
11/128,09511.05.2005US
Title (EN) METHOD FOR FOSTERING BONE FORMATION AND PRESERVATION
(FR) METHODE POUR STIMULER LA FORMATION ET LA PRESERVATION DES OS
Abstract:
(EN) A method of inducing bone formation in a subject in need of such inducement comprises the steps of mechanically inducing an increase in osteoblast activity in the subject and elevating blood concentration of at least one bone anabolic agent in the subject. The method steps may be performed in any order, but in sufficient time proximity that the elevated concentration of the anabolic agent and the mechanically induced increase in osteoblast activity overlaps. The method may additionally comprise providing the subject with an elevated blood concentration of at least one antiresorptive agent, wherein the elevated concentration is sufficient to prevent resorption of new bone growth produced due to the osteoblast activity. Use of the method permits targeting of specific bones of the subject for bone production and preservation, faster bone production and earlier discontinuation of bone anabolic pharmaceuticals. Kits adapted for performing the method are provided.
(FR) L'invention porte sur une méthode visant à induire la formation des os chez un sujet, cette méthode consistant à induire mécaniquement une augmentation de l'activité des ostéoblastes chez le sujet et à élever la concentration sanguine d'au moins un agent anabolique des os du sujet. Les étapes de cette méthode peuvent être effectuées dans n'importe quel ordre, mais sur une durée suffisante pour que la concentration élevée de l'agent anabolique et l'augmentation, induite mécaniquement, de l'activité des ostéoblastes se chevauchent. Cette méthode peut, additionnellement, consister à doter le sujet d'une concentration sanguine élevée d'au moins un inhibiteur de la résorption osseuse, la concentration sanguine élevée étant suffisante pour prévenir la résorption d'une nouvelle croissance osseuse due à l'activité des ostéoblastes. L'utilisation de cette méthode permet de cibler des os spécifiques du sujet pour la formation et la préservation des os, une formation plus rapide des os et une interruption précoce des produits pharmaceutiques anaboliques. L'invention porte également sur des kits adaptés pour réaliser cette méthode.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP1879608JP2008540522CN101217972CA2608016AU2005331907