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1. (WO2006122723) METHOD FOR THE PREVENTION AND/OR TREATMENT OF AUTOIMMUNE DISEASE OR ALLOGENEIC TRANSPLANT REJECTIONS

Pub. No.:    WO/2006/122723    International Application No.:    PCT/EP2006/004491
Publication Date: Nov 23, 2006 International Filing Date: May 12, 2006
IPC: C07K 16/24
A61P 29/00
Applicants: VAECGENE BIOTECH GMBH
MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN
FLÜGEL, Alexander
GRAU, Veronika
ZEIDLER, Reinhard
Inventors: FLÜGEL, Alexander
GRAU, Veronika
ZEIDLER, Reinhard
Title: METHOD FOR THE PREVENTION AND/OR TREATMENT OF AUTOIMMUNE DISEASE OR ALLOGENEIC TRANSPLANT REJECTIONS
Abstract:
The present invention relates to a method to use lycoricidinol (narciclasine) in order to suppress the immune system of mammals. Consequently, lycoricidinol can be used for the prevention and/or treatment of autoimmune disease as well as for the prevention and/or treatment of allogeneic transplant rejections and episodes of severe sepsis or septic shock. In another aspect thereof, the present invention relates to a method to avoid or treat multiple sclerosis (MS). In autoimmune encephalomyelitis (EAE), an experimental model related to multiple sclerosis (MS), the development of EAE is achieved by inhibiting the protein complex, S100A8/S100A9. Inhibition of the S100A8/S100A9 complex can be achieved either with a specific antibody or an inhibitor, like the alkaloid narciclasine.