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1. (WO2006122464) AN OLIGONUCLEOTIDE OR ITS FUNCTIONAL HOMOLOGUE, A COMPOSITION COMPRISING THE SAME AND A METHOD FOR TREATING B CELL NEOPLASM
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/122464    International Application No.:    PCT/CN2006/000216
Publication Date: 23.11.2006 International Filing Date: 13.02.2006
IPC:
A61K 31/7088 (2006.01), C07H 21/04 (2006.01), C12N 15/63 (2006.01), A61P 35/00 (2006.01), A61P 37/00 (2006.01)
Applicants: CHANGCHUN HUAPU BIOTECHNOLOGY CO., LTD. [CN/CN]; 4-28/1102-54#, Xinmin Street, Changchun, Jilin 130021 (CN) (For All Designated States Except US).
WANG, Li-ying [CN/CN]; (CN) (For US Only).
BAO, Mu-sheng [CN/CN]; (CN) (For US Only).
YU, Yong-li [CN/CN]; (CN) (For US Only)
Inventors: WANG, Li-ying; (CN).
BAO, Mu-sheng; (CN).
YU, Yong-li; (CN)
Agent: CHINA SCIENCE PATENT & TRADEMARK AGENT LTD.; 25/F., Bldg. B, Tsinghua Tongfang Hi-Tech Plaza, No.1, Wangzhuang Rd., Haidian District, Beijing 100083 (CN)
Priority Data:
200510069576.4 17.05.2005 CN
Title (EN) AN OLIGONUCLEOTIDE OR ITS FUNCTIONAL HOMOLOGUE, A COMPOSITION COMPRISING THE SAME AND A METHOD FOR TREATING B CELL NEOPLASM
(FR) OLIGONUCLEOTIDE OU SON HOMOLOGUE FONCTIONNEL, COMPOSITION LE COMPRENANT ET PROCEDE POUR LE TRAITEMENT D’UNE TUMEUR A LYMPHOCYTES B
Abstract: front page image
(EN)The invention provides an oligonucleotide with a sequence of SEQ ID NO:1 or its functional homolgue, a composition comprising the same and a method for treating B cell neoplasm by using the oligonucleotide or its functional homologue or the composition comprising the oligonucleotide. The oligonulceotide induces the apoptosis of B cell neoplastic cells, up-regulates CD40 on B cell neoplastic cells and stimulates the production of IL-10 from B cell neoplastic cells.
(FR)L’invention concerne un oligonucléotide avec une séquence de SEQ ID NO:1 ou son homologue fonctionnel, une composition le comprenant et un procédé pour le traitement d’une tumeur cancéreuse à lymphocytes B en utilisant l’oligonucléotide ou son homologue fonctionnel ou la composition comprenant l’oligonucléotide. L’oligonucléotide induit l’apoptose des cellules néoplasiques à lymphocytes B, régule par le haut le CD40 sur les cellules néoplasiques à lymphocytes B et stimule la production d’IL-10 à partir des cellules néoplasiques à cellules B.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)