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1. (WO2006122274) PHARMACEUTICAL FORMULATIONS OF RHODIOLA CRENULATA AND METHODS OF USE THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/122274    International Application No.:    PCT/US2006/018316
Publication Date: 16.11.2006 International Filing Date: 11.05.2006
IPC:
A61P 35/00 (2006.01), A61K 36/41 (2006.01)
Applicants: BAYSTATE HEALTH SYSTEMS, INC. [US/US]; 759 Chestnut Street, Springfield, MA 01199 (US) (For All Designated States Except US).
UNIVERSITY OF MASSACHUSETTS [US/US]; 225 Franklin Stret, Boston, MA 02110 (US) (For All Designated States Except US).
SCHNEIDER, Sallie, Smith [US/US]; (US) (For US Only).
SHETTY, Kalidas [US/US]; (US) (For US Only)
Inventors: SCHNEIDER, Sallie, Smith; (US).
SHETTY, Kalidas; (US)
Agent: SUNSTEIN, Bruce, D.; Bromberg & Sunstein LLP, 125 Summer Street, Boston, MA 02110-1618 (US)
Priority Data:
60/680,106 11.05.2005 US
Title (EN) PHARMACEUTICAL FORMULATIONS OF RHODIOLA CRENULATA AND METHODS OF USE THEREOF
(FR) FORMULATIONS PHARMACEUTIQUES DE RHODIOLA CRENULATA ET PROCEDES D'UTILISATION
Abstract: front page image
(EN)Isolated extracts of Rhodiola crenulata and their constituents sensitize tumor cells to cancer therapies, such as tamoxifen, retinoids, and radiation, and act to potentiate radiation therapy in the treatment of cancer, with or without adjuvant chemotherapy. Methods are provided for inhibiting the P13kinase/AKT pathway in cancer cells, a general survival pathway which leads to resistance of many tumors to typical therapies; decreasing cyclooxygenase (COX) activities in cancer cells, another pathway known to increase resistance to tumors; inhibiting telomerase activity in cancer cells, an activity notable for its ability to increase the life span of the cells; enhancing the ATM (Ataxia-Telangiectasia Mutated) response in cells, which is involved in DNA damage sensing and repair; modulating cellular response to oxidation, which effects the other signaling pathways on numerous levels; and altering usage of metabolic energy pathways.
(FR)Des extrait isolés de Rhodiola crenulata et leurs constituants sensibilisent les cellules cancéreuses aux thérapies anticancéreuses telles que par tamoxifène, rétinoïdes et rayonnement, et potentialisent les radiothérapies anticancéreuses, avec ou sans chimiothérapie adjuvante. L'invention concerne ainsi des procédés permettant d'inhiber le chemin P13-kinase/AKT dans les cellules cancéreuses, un chemin de survie générale qui conduit à la résistance de nombreuses tumeurs aux thérapies typiques; de diminuer les activités cyclooxygénase (COX) dans les cellules cancéreuses, un autre chemin connu pour augmenter la résistance aux tumeurs; d'inhiber l'activité télomérase dans les cellules cancéreuses, une activité notable pour son aptitude à augmenter la durée de vie des cellules; de renforcer la réponse ATM (Ataxie-Télangiectasie Mutée) dans les cellules, laquelle ATM est impliquée dans la détection et la réparation des dégâts d'ADN; de moduler la réponse cellulaire à l'oxydation, qui touche d'autres chemins de signalisation à de nombreux niveaux; et d'altérer l'utilisation des chemins d'énergies métaboliques.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)