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1. (WO2006122259) OPTICAL RESOLUTION OF 3-CARBAMOYLMETHYL-5-METHYL HEXANOIC ACID
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/122259    International Application No.:    PCT/US2006/018273
Publication Date: 16.11.2006 International Filing Date: 10.05.2006
IPC:
C07C 233/05 (2006.01), C07C 231/20 (2006.01), C07C 215/30 (2006.01), C07C 227/16 (2006.01), C07C 229/08 (2006.01), A61K 31/197 (2006.01), A61P 25/08 (2006.01)
Applicants: TEVA PHARMACEUTICAL INDUSTRIES LTD. [IL/IL]; 5 BASEL STREET, P.o. Box 3190, 49131 Petah Tiqva (IL) (AE, AG, AL, AM, AT, AU, AZ, BA, BE, BF, BG, BJ, BR, BW, BY, BZ, CA, CF, CG, CH, CI, CM, CN, CO, CR, CU, CY, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GW, HR, HU, ID, IE, IL, IN, IS, IT, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MC, MD, MG, MK, ML, MN, MR, MW, MX, MZ, NA, NE, NG, NI, NL, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SI, SK, SL, SM, SN, SY, SZ, TD, TG, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, YU, ZA, ZM, ZW only).
TEVA PHARMACEUTICALS USA, INC. [US/US]; 1090 HORSHAM ROAD, P.o. Box 1090, North Wales, PA 19454 (US) (BB only).
HEDVATI, Lilach [IL/IL]; (IL) (For US Only).
DEE NOOR, Ziv [IL/IL]; (IL) (For US Only).
SINGER, Claude [IL/IL]; (IL) (For US Only).
PILARSKI, Gideon [IL/IL]; (IL) (For US Only)
Inventors: HEDVATI, Lilach; (IL).
DEE NOOR, Ziv; (IL).
SINGER, Claude; (IL).
PILARSKI, Gideon; (IL)
Agent: BRAINARD, Charles, R.; Kenyon & Kenyon LLP, One Broadway, New York, NY 10004-1050 (US)
Priority Data:
60/679,784 10.05.2005 US
60/689,699 09.06.2005 US
60/733,009 02.11.2005 US
60/735,634 09.11.2005 US
60/740,950 29.11.2005 US
Title (EN) OPTICAL RESOLUTION OF 3-CARBAMOYLMETHYL-5-METHYL HEXANOIC ACID
(FR) RESOLUTION OPTIQUE DE L'ACIDE 3-CARBAMOYLMETHYL-5-METHYL HEXANOIQUE
Abstract: front page image
(EN)The invention relates to pure (R)-CMH and to the optical resolution of CMH- racemate, a key intermediate in the synthesis of (S)-Pregabalin. The invention also relates to the process for optically purifying (R)-CMH and to the process for isolatin (S)-CMH from the mother liquor.
(FR)L'invention concerne la purification de (R)-CMH et la résolution optique du CMH- racémate, un intermédiaire clé dans la synthèse de (S)-prégabaline. L'invention concerne également le procédé de purification optique de (R)-CMH et le procédé permettant d'isoler (S)-CMH de la solution mère.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)