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1. (WO2006122258) METHOD FOR THE PREPARATION OF PREGABALIN AND SALTS THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/122258    International Application No.:    PCT/US2006/018272
Publication Date: 16.11.2006 International Filing Date: 10.05.2006
IPC:
C07C 227/16 (2006.01), C07C 227/32 (2006.01), C07C 229/08 (2006.01)
Applicants: TEVA PHARMACEUTICAL INDUSTRIES LTD. [IL/IL]; 5 Basel Street, P.O. Box 3190, 49131 Petah Tiqva (IL) (AE, AG, AL, AM, AT, AU, AZ, BA, BE, BF, BG, BJ, BR, BW, BY, BZ, CA, CF, CG, CH, CI, CM, CN, CO, CR, CU, CY, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GW, HR, HU, ID, IE, IL, IN, IS, IT, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MC, MD, MG, MK, ML, MN, MR, MW, MX, MZ, NA, NE, NG, NI, NL, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SI, SK, SL, SM, SN, SY, SZ, TD, TG, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, YU, ZA, ZM, ZW only).
TEVA PHARMACEUTICALS USA, INC. [US/US]; 1090 Horsham Road, P.O. Box 1090, North Wales, PA 19454 (US) (BB only).
HEDVATI, Lilach [IL/IL]; (IL) (For US Only).
DEE NOOR, Ziv [IL/IL]; (IL) (For US Only).
SINGER, Claude [IL/IL]; (IL) (For US Only).
PILARSKI, Gideon [IL/IL]; (IL) (For US Only)
Inventors: HEDVATI, Lilach; (IL).
DEE NOOR, Ziv; (IL).
SINGER, Claude; (IL).
PILARSKI, Gideon; (IL)
Agent: BRAINARD, Charles, R.; Kenyon & Kenyon LLP, One Broadway, New York, NY 10004-1050 (US)
Priority Data:
60/679,784 10.05.2005 US
60/689,699 09.06.2005 US
Title (EN) METHOD FOR THE PREPARATION OF PREGABALIN AND SALTS THEREOF
(FR) PROCEDE POUR PREPARER DE LA PREGABALINE ET DES SELS DE CELLE-CI
Abstract: front page image
(EN)A process for the preparation of Pregabalin comprising: a) combining an alkali hydroxide and water, b) adding CMH at a temperature of about O° C to about 40° C; c) adding bromine, in a drop-wise manner, at a temperature of about O° C to about 40° C; d) heating; e) reacting with a strong mineral acid; f) extracting with a C4-8 alcohol, and g) mixing with a base to obtain Pregabalin. (Formula I)
(FR)La présente invention concerne un procédé pour préparer de la prégabaline. Ce procédé consiste a) à combiner un hydroxyde alcalin et de l'eau, b) à ajouter CMH à une température comprise entre environ 0 °C et environ 40 °C, c) à ajouter du brome goutte à goutte, à une température comprise entre environ 0 °C et environ 40 °C, d) à chauffer, e) à mettre en réaction avec un acide minéral fort, f) à extraire avec de l'alcool C4-8, puis g) à mélanger avec une base, afin d'obtenir de la prégabaline.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)