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1. (WO2006122178) A METHOD FOR MODULATING HLA CLASS II TUMOR CELL SURFACE EXPRESSION WITH A CYTOKINE MIXTURE

Pub. No.:    WO/2006/122178    International Application No.:    PCT/US2006/018055
Publication Date: Nov 16, 2006 International Filing Date: May 10, 2006
IPC: A61K 45/00
A61K 38/21
Applicants: CEL-SCI CORPORATION
TALOR, Eyal
Inventors: TALOR, Eyal
Title: A METHOD FOR MODULATING HLA CLASS II TUMOR CELL SURFACE EXPRESSION WITH A CYTOKINE MIXTURE
Abstract:
A method for altering the composition of tumor infiltrating mononuclear cells, increasing CD4+/CD8+ ratio, increasing tumor stroma/epithelial ratio and modulating HLA (Human Leukocyte Antigen) class II expression on a tumor cell surface with a serum-free and mitogen-free mixture having specific cytokine ratios from the group of IL-I β, TNF-α, IFN-Ϝ, GM-CSF, and Interleukin-2 (IL-2) with specific ratios of IL-I β, TNF-α, IFN-Ϝ, GM-CSF to IL- 2, respectively. The serum-free and mitogen-free mixtures comprised of cytokine ratios include Leukocyte Interleukin, Injection (LI) or Multikine®, which can be further used along or in combination with other drugs for the treatment of cancer thereby increasing the success of cancer treatment and the disease free survival of cancer patients.