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1. (WO2006121856) PYRIMIDINE-BASED NON-NUCLEOTIDE COMPOSITION AND METHOD FOR INHIBITING PLATELET AGGREGATION
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/121856    International Application No.:    PCT/US2006/017407
Publication Date: 16.11.2006 International Filing Date: 02.05.2006
Chapter 2 Demand Filed:    05.03.2007    
IPC:
A61K 31/70 (2006.01), A61K 31/7068 (2006.01)
Applicants: INSPIRE PHARMACEUTICALS INC. [US/US]; 4222 Emperor Blvd., Suite 200, Durham, North Carolina 27703 (US) (For All Designated States Except US).
DOUGLASS, James, G., III [US/US]; (US) (For US Only).
WATSON, Paul, S. [US/US]; (US) (For US Only).
SHAVER, Sammy, R. [US/US]; (US) (For US Only).
BEDNARSKI, Krzysztof [CA/US]; (US) (For US Only)
Inventors: DOUGLASS, James, G., III; (US).
WATSON, Paul, S.; (US).
SHAVER, Sammy, R.; (US).
BEDNARSKI, Krzysztof; (US)
Agent: KUNG, Viola, T.; Howrey LLP, 2941 Fairview Park Drive, Box 7, Falls Church, VA 22042 (US)
Priority Data:
60/678,890 05.05.2005 US
11/413,600 28.04.2006 US
Title (EN) PYRIMIDINE-BASED NON-NUCLEOTIDE COMPOSITION AND METHOD FOR INHIBITING PLATELET AGGREGATION
(FR) COMPOSITION NON NUCLEOTIDIQUE A BASE DE PYRIMIDINE ET METHODE PERMETTANT D'INHIBER L'AGREGATION PLAQUETTAIRE
Abstract: front page image
(EN)This invention is directed to a method of preventing or treating diseases or conditions associated with platelet aggregation. The method is also directed to a method of treating thrombosis or related disorders. The method comprises administering to a subject a pharmaceutical composition comprising an effective amount of a non-nucleotide pyrimidine-based compound, preferably a P2Y12 receptor antagonist compound, wherein said amount is effective to inhibit platelet aggregation. The compounds useful for this invention include compounds of general Formulae (I) and (Ia-Ic), or tautomers, salts, hydrates, and solvates thereof. The present invention also provides novel compounds of Formulae (I) and (Ia-Ic).
(FR)Cette invention concerne une méthode permettant d'empêcher ou de traiter des maladies ou des affections associées à l'agrégation plaquettaire. La présente invention concerne également une méthode permettant de traiter la thrombose ou les troubles associés. La méthode décrite dans cette invention consiste à administrer à un sujet une composition pharmaceutique contenant une quantité efficace d'un composé non nucléotidique à base de pyrimidine, de préférence, un composé antagoniste du récepteur P2Y12, en quantité suffisante pour inhiber l'agrégation plaquettaire. Les composés utilisés dans cette invention comprennent des composés représentés par les formules générales (I) et (Ia-Ic), ou des tautomères, des sels, des hydrates, et des solvates de ceux-ci. Cette invention concerne également des nouveaux composés représentés par les formules (I) et (Ia-Ic).
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)