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Machine translation
1. (WO2006121464) COMPOSITIONS FOR TREATING RESPIRATORY VIRAL INFECTIONS AND THEIR USE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/121464    International Application No.:    PCT/US2005/040048
Publication Date: 16.11.2006 International Filing Date: 04.11.2005
IPC:
C12N 15/11 (2006.01), C07K 14/11 (2006.01), C07K 14/135 (2006.01), A61K 48/00 (2006.01)
Applicants: INTRADIGM CORPORATION [US/US]; 12115 Parklawn Drive, Suite K, Rockville, MD 20852 (US) (For All Designated States Except US).
TANG, Qingquan [US/US]; (US) (For US Only).
LU, Patrick, Y. [US/US]; (US) (For US Only).
XIE, Frank, Y. [CN/US]; (US) (For US Only).
WOODLE, Martin, C. [US/US]; (US) (For US Only).
ZHENG, Bojian [CA/CN]; (CN) (For US Only)
Inventors: TANG, Qingquan; (US).
LU, Patrick, Y.; (US).
XIE, Frank, Y.; (US).
WOODLE, Martin, C.; (US).
ZHENG, Bojian; (CN)
Agent: AUER, Henry, E.; Proteus Patent Practice LLC, P.O. Box 1867, New Haven, CT 06508 (US)
Priority Data:
60/625,677 05.11.2004 US
PCT/US2005/003858 07.02.2005 US
Title (EN) COMPOSITIONS FOR TREATING RESPIRATORY VIRAL INFECTIONS AND THEIR USE
(FR) COMPOSITIONS POUR LE TRAITEMENT D'INFECTIONS VIRALES RESPIRATOIRES ET UTILISATIONS ASSOCIEES
Abstract: front page image
(EN)The invention provides siRNA compositions that interfere with viral replication in respiratory viral infections, including respiratory syncytial virus and avian influenza A, including the H5N1 strain. The invention further provides uses of the siRNA compositions to inhibit expression of viral genes in respiratory virus-infected cells, and to uses in the treatment of respiratory virus infections in a subject. Generally the invention provides polynucleotide that includes a first nucleotide sequence of 15 to 30 bases that targets the genome of a respiratory syncytial virus or an influenza A virus, a complement thereof, a double stranded polynucleotide or a hairpin polynucleotide. Additionally the invention provides vectors, cells and pharmaceutical compositions containing siRNA sequences.
(FR)L'invention concerne des compositions d'ARNsi qui gênent la réplication virale des infections virales respiratoires, y compris le virus syncytial respiratoire et la grippe aviaire A, dont la souche H5N1. Cette invention porte aussi sur des utilisations des compositions d'ARNsi afin d'inhiber l'expression des gènes viraux dans cellules infectées par le virus respiratoire, ainsi que sur des utilisations associées dans le traitement d'infections dues au virus respiratoire chez un sujet. Ladite invention se rapporte à un polynucléotide contenant une première séquence nucléotidique de 15 à 30 bases ciblant le génome d'un virus syncytial respiratoire ou d'un virus de la grippe A, à un complément de celui-ci, à un polynucléotide à double brin ou un polynucléotide en épingle à cheveux. Elle concerne également des vecteurs, des cellules et des compositions pharmaceutiques contenant les séquences d'ARNsi.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)