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1. (WO2006121218) N,N-SUBSTITUTED 3-AMINOPYRROLIDINE COMPOUNDS USEFUL AS MONOAMINES REUPTAKE INHIBITORS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/121218    International Application No.:    PCT/JP2006/309988
Publication Date: 16.11.2006 International Filing Date: 12.05.2006
IPC:
C07D 401/12 (2006.01), C07D 401/14 (2006.01), C07D 403/14 (2006.01), C07D 207/14 (2006.01), C07D 405/12 (2006.01), C07D 407/12 (2006.01), A61K 31/497 (2006.01), A61K 31/4439 (2006.01), A61K 31/40 (2006.01), A61P 25/00 (2006.01), C07D 413/12 (2006.01), C07D 413/14 (2006.01), C07D 417/12 (2006.01), C07D 417/14 (2006.01), C07D 407/14 (2006.01)
Applicants: OTSUKA PHARMACEUTICAL CO., LTD. [JP/JP]; 9, Kanda-Tsukasamachi 2-chome, Chiyoda-ku, Tokyo, 1018535 (JP) (For All Designated States Except US).
KURIMURA, Muneaki [JP/JP]; (JP) (For US Only).
TAIRA, Shinichi [JP/JP]; (JP) (For US Only).
TOMOYASU, Takahiro [JP/JP]; (JP) (For US Only).
ITO, Nobuaki [JP/JP]; (JP) (For US Only).
TAI, Kuninori [JP/JP]; (JP) (For US Only).
TAKEMURA, Noriaki [JP/JP]; (JP) (For US Only).
MATSUZAKI, Takayuki [JP/JP]; (JP) (For US Only).
MENJO, Yasuhiro [JP/JP]; (JP) (For US Only).
MIYAMURA, Shin [JP/JP]; (JP) (For US Only).
SAKURAI, Yohji [JP/JP]; (JP) (For US Only).
WATANABE, Akihito [JP/JP]; (JP) (For US Only).
SAKATA, Yasuyo [JP/JP]; (JP) (For US Only).
MASUMOTO, Takumi [JP/JP]; (JP) (For US Only).
AKAZAWA, Kohei [JP/JP]; (JP) (For US Only).
SUGINO, Haruhiko [JP/JP]; (JP) (For US Only).
AMADA, Naoki [JP/JP]; (JP) (For US Only).
OHASHI, Satoshi [JP/JP]; (JP) (For US Only).
SHINOHARA, Tomoichi [JP/JP]; (JP) (For US Only).
SASAKI, Hirofumi [JP/JP]; (JP) (For US Only).
MORITA, Chisako [JP/JP]; (JP) (For US Only).
YAMASHITA, Junko [JP/JP]; (JP) (For US Only).
NAKAJIMA, Satoko [JP/JP]; (JP) (For US Only)
Inventors: KURIMURA, Muneaki; (JP).
TAIRA, Shinichi; (JP).
TOMOYASU, Takahiro; (JP).
ITO, Nobuaki; (JP).
TAI, Kuninori; (JP).
TAKEMURA, Noriaki; (JP).
MATSUZAKI, Takayuki; (JP).
MENJO, Yasuhiro; (JP).
MIYAMURA, Shin; (JP).
SAKURAI, Yohji; (JP).
WATANABE, Akihito; (JP).
SAKATA, Yasuyo; (JP).
MASUMOTO, Takumi; (JP).
AKAZAWA, Kohei; (JP).
SUGINO, Haruhiko; (JP).
AMADA, Naoki; (JP).
OHASHI, Satoshi; (JP).
SHINOHARA, Tomoichi; (JP).
SASAKI, Hirofumi; (JP).
MORITA, Chisako; (JP).
YAMASHITA, Junko; (JP).
NAKAJIMA, Satoko; (JP)
Agent: SAEGUSA, Eiji; Kitahama TNK Building, 1-7-1, Doshomachi, Chuo-ku, Osaka-shi, Osaka 5410045 (JP)
Priority Data:
2005-141230 13.05.2005 JP
Title (EN) N,N-SUBSTITUTED 3-AMINOPYRROLIDINE COMPOUNDS USEFUL AS MONOAMINES REUPTAKE INHIBITORS
(FR) DÉRIVÉS DE 3-AMINOPYRROLIDINE N,N-SUBSTITUÉS POUVANT ÊTRE EMPLOYÉS EN TANT QU'INHIBITEURS DE LA RECAPTURE DE MONOAMINES
Abstract: front page image
(EN)The present invention provides a pyrrolidine compound of General Formula (1) or a salt thereof, wherein R¿101? and R¿102? are each independently a phenyl group or a pyridyl group, the phenyl group or the pyridyl group may have one or more substituents selected from halogen atoms and lower alkyl groups optionally substituted with one or more halogen atoms, etc. The pyrrolidine compound or a salt thereof of the present invention is usable to produce a pharmaceutical preparation having a wider therapeutic spectrum and being capable of exhibiting sufficient therapeutic effects after short-term administration.
(FR)La présente invention concerne un dérivé de pyrrolidine de Formule Générale (1) ou un sel de ce dérivé, où R¿101? et R¿102? représentent chacun de façon indépendante un groupement phényle ou un groupement pyridyle, ledit groupement phényle ou groupement pyridyle pouvant comporter un ou plusieurs substituants sélectionnés parmi les atomes d'halogène ou les groupements alkyle inférieurs éventuellement substitués par un ou plusieurs atomes d'halogène, etc. Ledit dérivé de pyrrolidine ou l'un de ses sels selon la présente invention peut être employé pour produire une préparation pharmaceutique de spectre thérapeutique plus étendu et susceptible de présenter des effets thérapeutiques suffisants à court terme après une administration.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)