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1. WO2006119593 - GENE-BASED ALGORITHMIC CANCER PROGNOSIS

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Publication Number WO/2006/119593
Publication Date 16.11.2006
International Application No. PCT/BE2006/000051
International Filing Date 15.05.2006
Chapter 2 Demand Filed 13.03.2007
IPC
G06F 19/20 2011.1
GPHYSICS
06COMPUTING; CALCULATING OR COUNTING
FELECTRIC DIGITAL DATA PROCESSING
19Digital computing or data processing equipment or methods, specially adapted for specific applications
10Bioinformatics, i.e. methods or systems for genetic or protein-related data processing in computational molecular biology
20for hybridisation or gene expression, e.g. microarrays, sequencing by hybridisation, normalisation, profiling, noise correction models, expression ratio estimation, probe design or probe optimisation
CPC
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 43/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
C12Q 1/6886
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6883for diseases caused by alterations of genetic material
6886for cancer
C12Q 2600/106
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
2600Oligonucleotides characterized by their use
106Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
C12Q 2600/112
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
2600Oligonucleotides characterized by their use
112Disease subtyping, staging or classification
C12Q 2600/118
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
2600Oligonucleotides characterized by their use
118Prognosis of disease development
Applicants
  • UNIVERSITE LIBRE DE BRUXELLES [BE]/[BE] (AllExceptUS)
  • SOTIRIOU, Christos [GR]/[BE] (UsOnly)
  • DELORENZI, Mauro [CH]/[CH] (UsOnly)
  • PICCART, Martine [BE]/[BE] (UsOnly)
Inventors
  • SOTIRIOU, Christos
  • DELORENZI, Mauro
  • PICCART, Martine
Agents
  • VAN MALDEREN, Joëlle
Priority Data
05447274.107.12.2005EP
60/680,54313.05.2005US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) GENE-BASED ALGORITHMIC CANCER PROGNOSIS
(FR) PRONOSTIC ALGORITHMIQUE DU CANCER BASE SUR LES GENES GENE-BASED ALGORITHMIC CANCER PROGNOSIS
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Abstract
(EN) The present invention is related to The methods and systems for prognosis determination in tumor samples, by measuring gene expression in a tumor sample and applying a gene-expression grade index (GGI) or a relapse score (RS) to yield a numerical risk score.
(FR) La présente invention concerne des méthodes et des systèmes qui permettent de déterminer un pronostic de prélèvements de tumeur. Les méthodes consistent à mesurer l'expression génique dans un prélèvement de tumeur et à appliquer un indice-qualité de l'expression génique (GGI) ou un indice de rechute (RS) pour obtenir un indice chiffré du risque.
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