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1. (WO2006119507) NON-NUCLEOTIDE COMPOSITION AND METHOD FOR INHIBITING PLATELET AGGREGATION
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/119507    International Application No.:    PCT/US2006/017781
Publication Date: 09.11.2006 International Filing Date: 05.05.2006
Chapter 2 Demand Filed:    05.12.2006    
IPC:
C07D 487/04 (2006.01), C07D 473/34 (2006.01), C07D 473/40 (2006.01), C07D 473/02 (2006.01), C07D 473/16 (2006.01), A61K 31/519 (2006.01), A61P 7/02 (2006.01)
Applicants: INSPIRE PHARMACEUTICALS, INC. [US/US]; 4222 Emperor Boulevard, Suite 470, Durham, North Carolina 27703 (US) (For All Designated States Except US).
DOUGLASS, James G., III [US/US]; (US) (For US Only).
PLOURDE, Robert, Jr. [US/US]; (US) (For US Only).
SHAVER, Sammy R. [US/US]; (US) (For US Only).
WATSON, Paul S. [US/US]; (US) (For US Only).
BOYER, José L. [US/US]; (US) (For US Only).
DECAMP, Jonathan B. [US/US]; (US) (For US Only).
SAMUELSON, Carl A. [US/US]; (US) (For US Only)
Inventors: DOUGLASS, James G., III; (US).
PLOURDE, Robert, Jr.; (US).
SHAVER, Sammy R.; (US).
WATSON, Paul S.; (US).
BOYER, José L.; (US).
DECAMP, Jonathan B.; (US).
SAMUELSON, Carl A.; (US)
Agent: KUNG, Viola T.; Howrey LLP, 2941 Fairview Park Drive, Box 7, Falls Church, Virginia 22042 (US)
Priority Data:
11/124,619 05.05.2005 US
Title (EN) NON-NUCLEOTIDE COMPOSITION AND METHOD FOR INHIBITING PLATELET AGGREGATION
(FR) COMPOSITION NON NUCLEOTIDIQUE ET TECHNIQUE D'INHIBITION D'AGREGATION DE PLAQUETTES
Abstract: front page image
(EN)This invention is directed to a method of preventing or treating diseases or conditions associated with platelet aggregation. The method is also directed to a method of treating thrombosis or related disorders. The method comprises administering to a subject a pharmaceutical composition comprising an effective amount of a non-nucleotide compound, preferably a P2Y12 receptor antagonist compound, wherein said amount is effective to inhibit platelet aggregation. The compounds useful for this invention include compounds of general Formulae I and III-XII, or salts, hydrates, and solvates thereof. The present invention also provides novel compounds of Formulae I and III-XII.
(FR)La présente invention concerne une technique permettant d'empêcher des maladies ou de traiter des maladies et des pathologies associées à l'agrégation des plaquettes. Cette technique concerne aussi une technique de traitement de thromboses et de troubles associés. Cette technique consiste à administrer à un sujet une composition pharmaceutique comprenant une quantité efficace d'un composé non nucléotidique, de préférence un composé antagoniste du récepteur P2Y12, cette quantité étant efficace pour inhiber l'agrégation des plaquettes. Les composés convenant pour cette invention comprennent des composés représentés par les formule générale I et III-XII, ou des sels, des hydrates et des solvates de ceux-ci. Cette invention concerne aussi de nouveaux composés représentés par les formules I et III-XII.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)