WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2006119083) TREATING GASTROINTESTINAL DISEASES WITH MODULATION OF RETONIC ACID
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/119083    International Application No.:    PCT/US2006/016384
Publication Date: 09.11.2006 International Filing Date: 28.04.2006
IPC:
A01N 63/00 (2006.01), A61K 45/00 (2006.01), A61K 47/00 (2006.01), C12N 5/0784 (2010.01)
Applicants: CBR INSTITUTE FOR BIOMEDICAL RESEARCH, INC. [US/US]; 800 Huntington Avenue, Boston, Massachusetts 02115 (US) (For All Designated States Except US).
VON ANDRIAN, Ulrich H. [US/US]; (US) (For US Only).
MORE, Jorge Rodrigo [US/US]; (US) (For US Only)
Inventors: VON ANDRIAN, Ulrich H.; (US).
MORE, Jorge Rodrigo; (US)
Agent: GOSZ, William; GOSZ AND PARTNERS, LLP, 450 Bedford Street, Lexington, Massachusetts 02420 (US)
Priority Data:
60/676,249 29.04.2005 US
Title (EN) TREATING GASTROINTESTINAL DISEASES WITH MODULATION OF RETONIC ACID
(FR) TRAITEMENT DES MALADIES GASTRO-INTESTINALES AU MOYEN DE MODULATEURS D'ACIDE RETINOIQUE
Abstract: front page image
(EN)T cells are programmed to target the gastrointestinal tract by activation with dendritic cells capable of producing and/or transporting retinoic acid. Methods for using the programmed dendritic cells and/or T and/or B cells to treat a variety of pathogens and infectious agents residing in the intestine are also disclosed. Similarly, inhibitors of retinoic acid synthesis by dendritic cells or other cells in the gut, and inhibitors of retinoic acid receptors in T and/or B cells or other cells in the intestinal mucosa, are 'disclosed for treating a variety of gastrointestinal autoimmune diseases such as inflammatory bowel disease and celiac disease.
(FR)Selon l'invention, des lymphocytes T sont programmés pour cibler le tractus gastro-intestinal par activation au moyen de cellules dendritiques aptes à produire et/ou transporter de l'acide rétinoïque. L'invention concerne également des méthodes d'utilisation des cellules dendritiques programmées et/ou de lymphocytes T et/ou B pour traiter divers agents pathogènes et infectieux résidant dans l'intestin. L'invention concerne encore des inhibiteurs de synthèse d'acide rétinoïque par des cellules dendritiques ou d'autres cellules dans l'intestin, ainsi que des inhibiteurs de récepteurs d'acide rétinoïque dans des lymphocytes T et/ou B ou d'autres cellules dans la muqueuse intestinale, utilisés dans le traitement de diverses maladies auto-immunes gastro-intestinales, telles que la maladie intestinale inflammatoire et la maladie coeliaque.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)