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1. WO2006118248 - CELL GROWTH INHIBITORY MEMBER, CELL METASTASIS INHIBITORY MEMBER, METHOD OF INHIBITING CELL GROWTH, METHOD OF INHIBITING CELL METASTASIS, LAYERED FILM AND MEDICAL INSTRUMENT

Publication Number WO/2006/118248
Publication Date 09.11.2006
International Application No. PCT/JP2006/308980
International Filing Date 28.04.2006
IPC
A61L 29/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
29Materials for catheters or for coating catheters
A61L 31/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
31Materials for other surgical articles
A61B 17/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
17Surgical instruments, devices or methods, e.g. tourniquets
A61F 2/84 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
2Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
82Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
84Instruments specially adapted for their placement or removal
CPC
A61L 27/34
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for ; grafts or; prostheses or for coating ; grafts or; prostheses
28Materials for coating prostheses
34Macromolecular materials
A61L 29/085
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
29Materials for catheters, ; medical tubing, cannulae, or endoscopes; or for coating catheters
08Materials for coatings
085Macromolecular materials
A61L 31/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
31Materials for other surgical articles ; , e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
08Materials for coatings
10Macromolecular materials
Applicants
  • 独立行政法人科学技術振興機構 Japan Science and Technology Agency [JP]/[JP] (AllExceptUS)
  • 国立大学法人北海道大学 National University Corporation Hokkaido University [JP]/[JP] (AllExceptUS)
  • ゼオンメディカル株式会社 ZEON MEDICAL INC. [JP]/[JP] (AllExceptUS)
  • 田中 賢 TANAKA, Masaru [JP]/[JP] (UsOnly)
  • 濱田 淳一 HAMADA, Junichi (UsOnly)
  • 豊川 秀英 TOYOKAWA, Yoshihide [JP]/[JP] (UsOnly)
  • 山本 貞明 YAMAMOTO, Sada-aki (UsOnly)
  • 下村 政嗣 SHIMOMURA, Masatsugu (UsOnly)
Inventors
  • 田中 賢 TANAKA, Masaru
  • 濱田 淳一 HAMADA, Junichi
  • 豊川 秀英 TOYOKAWA, Yoshihide
  • 山本 貞明 YAMAMOTO, Sada-aki
  • 下村 政嗣 SHIMOMURA, Masatsugu
Agents
  • 大石 治仁 OHISHI, Haruhito
Priority Data
2005-13332028.04.2005JP
2005-16204301.06.2005JP
2005-16204401.06.2005JP
Publication Language Japanese (ja)
Filing Language Japanese (JA)
Designated States
Title
(EN) CELL GROWTH INHIBITORY MEMBER, CELL METASTASIS INHIBITORY MEMBER, METHOD OF INHIBITING CELL GROWTH, METHOD OF INHIBITING CELL METASTASIS, LAYERED FILM AND MEDICAL INSTRUMENT
(FR) ELEMENT D'INHIBITION DE CROISSANCE CELLULAIRE, ELEMENT D'INHIBITION DE METASTASES CELLULAIRES, PROCEDE D'INHIBITION DE CROISSANCE CELLULAIRE, PROCEDE D'INHIBITION DE METASTASES CELLULAIRES, FILM EN PLUSIEURS COUCHES ET INSTRUMENT MEDICAL
(JA) 細胞増殖抑制部材、細胞転移抑制部材、細胞増殖抑制方法、細胞転移抑制方法、積層フィルムおよび医療用具
Abstract
(EN) (1) A cell growth inhibitory member characterized by having a porous structure; (2) a method of inhibiting cell growth characterized by comprising bringing a part having the porous structure formed therein of the above cell growth inhibitory member into contact with cells and thus inhibiting the growth of the cells in the contact part; (3) a layered film composed of a first resin film and a second resin film, which is the above cell growth inhibitory member, layered thereon; (4) a cell metastasis inhibitory member characterized by having a porous structure; (5) a method of inhibiting cell metastasis characterized by comprising bringing a part having the porous structure formed therein of the above cell metastasis inhibitory member into contact with cells and thus inhibiting the metastasis of the cells in the contact part; (6) a layered film composed of a first resin film and a second resin film, which is the above cell metastasis inhibitory member, layered thereon; and (7) a medical instrument characterized in that the surface of the medical instrument is entirely or partly coated with the above cell growth inhibitory member or the above cell metastasis inhibitory member. Thus, an excellent cell growth inhibitory effect or an excellent cell metastasis inhibitory effect can be obtained without resorting to a physiologically active substance such as carcinostatic agent.
(FR) La présente invention concerne (1) un élément d'inhibition de croissance cellulaire caractérisé en ce qu'il présente une structure poreuse; (2) un procédé d'inhibition de croissance cellulaire caractérisé en ce qu'il comprend la mise en contact d'une partie présentant la structure poreuse formée dans celle-ci de l'élément d'inhibition de croissance cellulaire mentionné ci-dessus avec des cellules et inhibe ainsi la croissance des cellules dans la partie de contact; (3) un film en plusieurs couches composé d'un premier film de résine et d'un deuxième film de résine, qui est l'élément d'inhibition de croissance cellulaire mentionné ci-dessus, appliqué en couche sur celui-ci; (4) un élément d'inhibition de métastases cellulaires caractérisé en ce qu'il a une structure poreuse; (5) un procédé d'inhibition des métastases cellulaires caractérisé en ce qu'il comprend la mise en contact d'une partie présentant la structure poreuse formée dans celle-ci de l'élément d'inhibition de métastases cellulaires mentionné ci-dessus avec des cellules et inhibe ainsi les métastases des cellules dans la partie de contact; (6) un film en plusieurs couches composé d'un premier film de résine et d'un deuxième film de résine, qui est l'élément d'inhibition de métastases cellulaires mentionné ci-dessus, appliqué en couche sur celui-ci; et (7) un instrument médical caractérisé en ce que la surface de l'instrument médical est entièrement ou partiellement recouverte avec l'élément d'inhibition de croissance cellulaire mentionné ci-dessus ou l'élément d'inhibition de métastases cellulaires mentionné ci-dessus. Ainsi, on peut obtenir un excellent effet d'inhibition de croissance cellulaire ou un excellent effet d'inhibition de métastases cellulaires sans avoir recours à une substance physiologiquement active telle qu'un agent carcinostatique.
(JA)  本発明は、(1)多孔構造を有することを特徴とする細胞増殖抑制部材、(2)前記細胞増殖抑制部材の多孔構造が形成されている部分を細胞に接触させることにより、該接触部における細胞の増殖を抑制することを特徴とする細胞増殖抑制方法、(3)第1の樹脂フィルムと、前記細胞増殖抑制部材である第2の樹脂フィルムが積層された積層フィルム、(4)多孔構造を有することを特徴とする細胞転移抑制部材、(5)前記細胞転移抑制部材の多孔構造が形成されている部分を細胞に接触させることにより、該接触部における細胞の転移を抑制することを特徴とする細胞転移抑制方法、(6)第1の樹脂フィルムと、前記細胞転移抑制部材である第2の樹脂フィルムが積層された積層フィルム、及び(7)医療用具基材の表面の全部または一部を、前記細胞増殖抑制部材、または、前記細胞転移抑制部材で被覆してなることを特徴とする医療用具である。本発明によれば、制ガン剤等の生理活性物質を使用することなくとも、優れた細胞増殖抑制効果又は細胞転移抑制効果を得ることができる。
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