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1. (WO2006118173) TRENADERMAL ABSORPTION PREPARATION
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/118173    International Application No.:    PCT/JP2006/308806
Publication Date: 09.11.2006 International Filing Date: 27.04.2006
IPC:
A61K 31/5575 (2006.01), A61K 9/06 (2006.01), A61K 9/70 (2006.01), A61K 47/06 (2006.01), A61K 47/10 (2006.01), A61K 47/12 (2006.01), A61K 47/14 (2006.01), A61K 47/18 (2006.01), A61K 47/32 (2006.01), A61K 47/34 (2006.01), A61K 47/44 (2006.01), A61P 19/08 (2006.01), A61P 43/00 (2006.01)
Applicants: ONO PHARMACEUTICAL CO., LTD. [JP/JP]; 1-5, Doshomachi 2-chome, Chuo-ku, Osaka-shi, Osaka 5418526 (JP) (For All Designated States Except US).
NISHIURA, Akio [JP/JP]; (JP) (For US Only).
SUGIHARA, Hikaru [JP/JP]; (JP) (For US Only).
ARAI, Harumi [JP/JP]; (JP) (For US Only).
KANAJI, Toshiya [JP/JP]; (JP) (For US Only)
Inventors: NISHIURA, Akio; (JP).
SUGIHARA, Hikaru; (JP).
ARAI, Harumi; (JP).
KANAJI, Toshiya; (JP)
Agent: OHIE, Kunihisa; OHIE Patent Office Selva-Ningyocho 6F 14-6, Nihonbashi-Ningyocho 2-chome Chuo-ku, Tokyo 103-0013 (JP)
Priority Data:
2005-130688 28.04.2005 JP
Title (EN) TRENADERMAL ABSORPTION PREPARATION
(FR) PRÉPARATION POUR ABSORPTION TRANSDERMALE
(JA) 経皮吸収製剤
Abstract: front page image
(EN)A transdermal absorption preparation controlling the drug concentration in blood which contains an ester compound of 4-{[2-(1R,2R,3R)-3-hydroxy-2-{(1E,3S)-3-hydroxy-4-[3-(methoxymethyl)phenyl]buta-1-enyl}-5-oxocyclopentyl)ethyl]sulfanyl}butanonic acid. This transdermal absorption preparation controlling the drug concentration in blood makes it possible to stably sustain the concentration of the active compound in the blood and is highly safe without showing any side effects. Therefore, it is usable as a transdermal absorption preparation which can be continuously administered.
(FR)L’invention concerne une préparation pour absorption transdermale contrôlant la concentration sanguine du médicament qui contient un composé ester de l’acide 4-{[2-(1R,2R,3R)-3-hydroxy-2-{(1E,3S)-3-hydroxy-4-[3-(méthoxyméthyl)phényl]buta-1-enyl}-5-oxocyclopentyl)éthyl]sulfanyl} butanonique. Cette préparation pour absorption transdermale contrôlant la concentration sanguine du médicament permet de maintenir de façon stable la concentration sanguine du composé actif. Elle est très sûre et ne cause pas d’effet secondaire. Par conséquent, elle est utilisable comme préparation pour absorption transdermale pouvant être administrée de façon continue.
(JA) 本発明は、4-{[2-((1R,2R,3R)-3-ヒドロキシ-2-{(1E,3S)-3-ヒドロキシ-4-[3-(メトキシメチル)フェニル]ブタ-1-エニル}-5-オキソシクロペンチル)エチル]スルファニル}ブタン酸のエステル体および外用剤用基剤を含有する血中濃度調節型経皮吸収製剤に関する。本発明の血中濃度調節型経皮吸収製剤は、本発明の活性本体の血中濃度を安定的に持続させ、かつ副作用がなく安全であるため、持続投与が可能な経皮吸収製剤として利用できる。
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)