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Machine translation
1. (WO2006117782) RECOMBINANT ANTIBODIES AGAINST CD55 AND CD59 AND USES THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/117782    International Application No.:    PCT/IL2006/000521
Publication Date: 09.11.2006 International Filing Date: 01.05.2006
IPC:
C12P 21/08 (2006.01), C12N 15/00 (2006.01), C07H 21/00 (2006.01)
Applicants: QUARK PHARMACEUTICALS, INC. [US/US]; 6501 Dumbarton Circle, Fremont, California 94555 (US) (For All Designated States Except US).
MARZARI, Roberto [IT/IT]; (IT) (For US Only).
SBLATTERO, Daniele [IT/IT]; (IT) (For US Only).
TEDESCO, Francesco [IT/IT]; (IT) (For US Only).
QBI ENTERPRISES LTD. [IL/IL]; 3 Meir Weisgall Street, Weizman Science Park, P.o.box 4071, 7040 Nes Zionna (IL) (BA only)
Inventors: MARZARI, Roberto; (IT).
SBLATTERO, Daniele; (IT).
TEDESCO, Francesco; (IT)
Common
Representative:
QBI ENTERPRISES LTD.; 3 Meir Weisgall Street, Weizman Science Park, P.o.box 4071, 7040 Nes Zionna (IL)
Priority Data:
60/677,752 04.05.2005 US
60/699,024 13.07.2005 US
60/733,950 03.11.2005 US
Title (EN) RECOMBINANT ANTIBODIES AGAINST CD55 AND CD59 AND USES THEREOF
(FR) ANTICORPS RECOMBINANTS DIRIGES CONTRE CD55 ET CD59 ET LEUR UTILISATION
Abstract: front page image
(EN)The present invention relates to recombinant antibody molecules and functional fragments thereof, useful for neutralizing the complement regulatory proteins CD55 and CD59, compositions comprising the recombinant molecules and methods of using the recombinant molecules for controlling complement resistance in cancer. The present invention further relates to heterodimeric diabody molecules comprising variable regions specific for CD55/CD59 and CD20.
(FR)La présente invention concerne des molécules d'anticorps recombinants et leurs fragments fonctionnels, utiles pour neutraliser les protéines régulatrices de compléments CD55 et CD59, des compositions comprenant les molécules recombinantes et des procédés pour utiliser les molécules recombinantes afin de contrôler la résistance des compléments lors d'un cancer. La présente invention concerne aussi des molécules de diacorps hétérodimériques comprenant des régions variables spécifiques pour CD55/CD59 et CD20.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)