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1. (WO2006117743) SUBSTITUTED AROMATIC COMPOUNDS AS ANTIDIABETIC AGENTS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/117743    International Application No.:    PCT/IB2006/051346
Publication Date: 09.11.2006 International Filing Date: 28.04.2006
IPC:
C07D 213/30 (2006.01), C07D 263/58 (2006.01), C07D 277/82 (2006.01), C07D 213/74 (2006.01), C07D 265/36 (2006.01), C07D 239/90 (2006.01), C07D 279/16 (2006.01), A61K 31/41 (2006.01), A61K 31/435 (2006.01), A61K 31/495 (2006.01), A61K 31/535 (2006.01), A61P 3/10 (2006.01)
Applicants: RANBAXY LABORATORIES LIMITED [IN/IN]; Plot No. 90, Sector 32, Gurgaon, Haryana 122001 (IN) (For All Designated States Except US).
SATTIGERI, Jitendra, A. [IN/IN]; (IN) (For US Only).
KUNDU, Mrinalkanti [IN/IN]; (IN) (For US Only).
SHARMA, Lalima [IN/IN]; (IN) (For US Only).
GUPTA, Priya [IN/IN]; (IN) (For US Only).
KANDALKAR, Sachin, Ramesh [IN/IN]; (IN) (For US Only).
THANGATHIRUPATHY, Srinivasan [IN/IN]; (IN) (For US Only)
Inventors: SATTIGERI, Jitendra, A.; (IN).
KUNDU, Mrinalkanti; (IN).
SHARMA, Lalima; (IN).
GUPTA, Priya; (IN).
KANDALKAR, Sachin, Ramesh; (IN).
THANGATHIRUPATHY, Srinivasan; (IN)
Common
Representative:
RANBAXY LABORATORIES LIMITED; c/o DESHMUKH, Jay R., 600 College Road East, Suite 2100, Princeton, NJ 08540 (US)
Priority Data:
1109/DEL/2005 03.05.2005 IN
Title (EN) SUBSTITUTED AROMATIC COMPOUNDS AS ANTIDIABETIC AGENTS
(FR) COMPOSES AROMATIQUES SUBSTITUES, AGENTS ANTI-DIABETIQUES
Abstract: front page image
(EN)The present invention relates to substituted aromatic compounds, which have PPAR modulating activity, and hence can be used as anti-diabetic agents. Compounds described herein can be used as peroxisome proliferation activated receptor (PPAR) modulators. Such compounds can also be used as therapeutic agents for treating diseases and conditions mediated through any of the isoforms of PPAR, diabetes and diabetes-associated complications, diseases or conditions in which insulin resistance is the central pathophysiological mechanism and diseases or conditions such as Type II diabetes, dyslipidaemia, hypertension, coronary heart disease, cardiovascular disease, atherosclerosis, nephrosclerosis, polycystic ovarian syndrome, eating disorders, diabetes nephropathy, glomerulonephritis, glomerularsclerosis, nephrotic syndrome, psoriasis or obesity. Processes for the preparation of the described compounds, pharmaceutical compositions containing such compounds, and methods for treating diabetes mellitus and diseases and conditions mediated through insulin resistance are also provided.
(FR)L'invention porte sur des composés aromatiques substitués à activité modulatrice du PPAR (récepteur activé par le proliférateur du péroxysome) pouvant de ce fait servir d'agents anti-diabétiques, de par de leur caractère de modulateurs du PPAR. De tels composés peuvent servir à traiter des maladies et états médiés par les isoformes du PPAR, dont le diabète et les complications associées au diabète, et les maladies ou états dont la résistance à l'insuline constitue le mécanisme pathophysiologique central, et des maladies ou états tels que: le diabète de type II, la dyslipidémie, l'hypertension, les maladies coronariennes, les maladies cardio-vasculaires, l'athérosclérose, la néphrosclérose, le syndrome polykystique ovarien, les troubles de l'alimentation, les néphropathies diabétiques, les néphrites glomérulaires, la sclérose glomérulaire, le syndrome néphrotique, le psoriasis ou l'obésité. L'invention porte également sur les procédés de préparation des composés décrits, sur des préparations pharmaceutiques les contenant, et sur des méthodes de traitement du diabète sucré et des maladies et états médiés par la résistance à l'insuline.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)