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1. (WO2006117735) NOVEL ADENYL DINUCLEOTIDES WITH ANTITUMOUR ACTIVITY AND A METHOD FOR PREPARING THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/117735    International Application No.:    PCT/IB2006/051330
Publication Date: 09.11.2006 International Filing Date: 28.04.2006
IPC:
C07H 21/04 (2006.01)
Applicants: UNIVERSITA' DEGLI STUDI DI GENOVA [IT/IT]; Via Balbi 5, I-16126 Genova (IT) (For All Designated States Except US).
CENTRO BIOTECNOLOGIE AVANZATE [IT/IT]; Largo Rosanna Benzi 10, I-16132 Genova (IT) (For All Designated States Except US).
BASILE, Giovanna [IT/IT]; (IT) (For US Only).
BENATTI, Umberto [IT/IT]; (IT) (For US Only).
BRUZZONE, Santina [IT/IT]; (IT) (For US Only).
DAMONTE, Gianluca [IT/IT]; (IT) (For US Only).
DE FLORA, Antonio [IT/IT]; (IT) (For US Only).
FATTORUSSO, Ernesto [IT/IT]; (IT) (For US Only).
FRANCO, Luisa [IT/IT]; (IT) (For US Only).
GUIDA, Lucrezia [IT/IT]; (IT) (For US Only).
TAGLIALATELA-SCAFATI, Orazio [IT/IT]; (IT) (For US Only).
ZOCCHI, Elena [IT/IT]; (IT) (For US Only)
Inventors: BASILE, Giovanna; (IT).
BENATTI, Umberto; (IT).
BRUZZONE, Santina; (IT).
DAMONTE, Gianluca; (IT).
DE FLORA, Antonio; (IT).
FATTORUSSO, Ernesto; (IT).
FRANCO, Luisa; (IT).
GUIDA, Lucrezia; (IT).
TAGLIALATELA-SCAFATI, Orazio; (IT).
ZOCCHI, Elena; (IT)
Agent: COMOGLIO, Elena; Corso Emilia 8, I-10152 Torino (IT)
Priority Data:
TO2005A000298 02.05.2005 IT
Title (EN) NOVEL ADENYL DINUCLEOTIDES WITH ANTITUMOUR ACTIVITY AND A METHOD FOR PREPARING THEREOF
(FR) NOUVEAUX DINUCLEOTIDES D'ADENYLE PRESENTANT UNE ACTIVITE ANTITUMORALE, PROCEDE DE PREPARATION DE CES DERNIERS
Abstract: front page image
(EN)The invention relates to novel adenyl dinucleotides which are isomers of the dinucleotide Ap2A, having formulae (I) and (II) . The dinucleotides of the invention have antitumour activity, particularly against tumours of haematological origin, such as for example leukaemias and lymphomas. The invention further relates to the use of such dinucleotides as antitumour medicaments. Finally, the invention relates to an enzymatic method for preparing the dinucleotides of formulae (I) and (II) and to an enzymatic assay method for the dinucleotide of formula (I) which is based on its complete conversion to NAD+ .
(FR)La présente invention concerne de nouveaux dinucléotides d'adényle qui sont des isomères du dinucléotide Ap2A, représentés par les formules (I) et (II). Les dinucléotides selon l'invention possèdent une activité antitumorale notamment contre les tumeurs d'origine hématologique, telles que par exemple, les leucémies et les lymphomes. Cette invention se rapporte également à l'utilisation de tels dinucléotides en tant que médicaments antitumoraux. Pour terminer, cette invention concerne un procédé de préparation enzymatique des dinucléotides représentés par les formules (I) et (II) et un procédé de dosage enzymatique du dinucléotide représenté par la formule (I) qui repose sur sa complète conversion en NAD+. Formules (I) et (II)
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: Italian (IT)