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1. (WO2006117681) NOVEL THERAPIES AND METHODS OF SCREENING FOR THERAPEUTIC COMPOUNDS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/117681    International Application No.:    PCT/IB2006/001409
Publication Date: 09.11.2006 International Filing Date: 03.05.2006
IPC:
G01N 33/50 (2006.01)
Applicants: NYA HAMLET PHARMA AB [DK/DK]; NatImmune A/S, Fruebjergvej 3, 2100 Copenhagen Ø, Denmark (DK) (For All Designated States Except US).
SVANBORG, Catharina [SE/SE]; (SE) (For US Only).
GUSTAFFSON, Lotta [SE/SE]; (DE) (For US Only)
Inventors: SVANBORG, Catharina; (SE).
GUSTAFFSON, Lotta; (DE)
Agent: HøIBERG, A/S; St. Kongensgade 59A, DK-1264 Copenhagen K (DK)
Priority Data:
0508880.2 03.05.2005 GB
Title (EN) NOVEL THERAPIES AND METHODS OF SCREENING FOR THERAPEUTIC COMPOUNDS
(FR) NOUVELLES THERAPIES ET PROCEDES DE CRIBLAGE DE COMPOSES THERAPEUTIQUES
Abstract: front page image
(EN)A method for screening test substances for use in killing cells, said method comprising contacting a test substance with a proteasome and detecting an interaction therebetween which results in change in structure of the proteasome. Substances identified in this way are useful in the treatment of cancer, as well as virus infected cells and bacteria, and form a further aspect of the invention.
(FR)L'invention concerne un procédé de criblage de substances pour essai utilisées pour tuer des cellules. Ce procédé consiste à mettre en contact une substance pour essai avec un protéasome et à détecter une interaction entre les deux résultant en une modification de structure du protéasome. Les substances identifiées de cette manière sont utilisées dans le traitement du cancer, ainsi des cellules infectées par un virus et des bactéries, et constituent un autre aspect de l'invention.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)