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1. WO2006117600 - DOUBLE-STRANDED SYNTHETIC OLIGONUCLEOTIDES USEFUL FOR INDUCING APOPTOSIS OF OSTEOCLASTS FOR THE TREATMENT OF OSTEOPENIC PATHOLOGIES

Publication Number WO/2006/117600
Publication Date 09.11.2006
International Application No. PCT/IB2006/000741
International Filing Date 30.03.2006
IPC
C12N 15/11 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
A61K 31/713 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7088Compounds having three or more nucleosides or nucleotides
713Double-stranded nucleic acids or oligonucleotides
A61P 19/08 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19Drugs for skeletal disorders
08for bone diseases, e.g. rachitism, Paget's disease
CPC
A61P 19/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19Drugs for skeletal disorders
A61P 19/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19Drugs for skeletal disorders
08for bone diseases, e.g. rachitism, Paget's disease
C12N 15/113
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
C12N 2310/13
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
2310Structure or type of the nucleic acid
10Type of nucleic acid
13Decoys
Applicants
  • UNIVERSITA' DEGLI STUDI DI FERRARA [IT]/[IT] (AllExceptUS)
  • ASSOCIAZIONE VENETA PER LA LOTTA ALLA TALASSEMIA [IT]/[IT] (AllExceptUS)
  • GAMBARI, Roberto [IT]/[IT] (UsOnly)
  • PENOLAZZI, Letizia [IT]/[IT] (UsOnly)
  • PIVA, Roberta [IT]/[IT] (UsOnly)
Inventors
  • GAMBARI, Roberto
  • PENOLAZZI, Letizia
  • PIVA, Roberta
Agents
  • COMOGLIO, Elena,
Priority Data
TO2005A00021231.03.2005IT
Publication Language English (EN)
Filing Language Italian (IT)
Designated States
Title
(EN) DOUBLE-STRANDED SYNTHETIC OLIGONUCLEOTIDES USEFUL FOR INDUCING APOPTOSIS OF OSTEOCLASTS FOR THE TREATMENT OF OSTEOPENIC PATHOLOGIES
(FR) OLIGONUCLEOTIDES SYNTHETIQUES DOUBLE BRIN CONVENANT POUR INDUIRE L'APOPTOSE D'OSTEOCLASTES DESTINES AU TRAITEMENT DE PATHOLOGIES OSTEOPENIQUES
Abstract
(EN)
The invention relates to a synthetic double- stranded oligonucleotide capable of modifying the molecular phenotype of osteoclasts and increasing the expression of the oestrogen alpha receptor gene. Pharmaceutical compositions comprising the oligonucleotide according to the invention are also described, as well as therapeutic applications of that oligonucleotide, in particular for the treatment of osteopenic diseases such as for example osteoporosis . The oligonucleotide according to the invention is characterised in that it comprises the sequence 5'-ATTTATTTTCAATACTGACT-3' or a fragment or a mutant thereof .
(FR)
La présente invention concerne un oligo nucléotide synthétique double bras incapable de modifier le phénotype moléculaire de rester aux classes et d'augmenter l'expression de gènes récepteurs d'alpha oestrogène. Cette invention concerne aussi des compositions pharmaceutiques comprenant sept polygones nucléotides ainsi que des applications thérapeutiques de cette polygone que si de, en particulier pour le traitement de maladie ostéopénique telle que par exemple ostéoporose. Polygones nucléotides de cette invention se caractérisant ce qu'il comprend la séquence ou un fragment ou à mi-temps de celle-ci.
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