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Machine translation
1. (WO2006117567) ALPHA AMINOACID ESTER-DRUG CONJUGATES HYDROLYSABLE BY CARBOXYLESTERASE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/117567    International Application No.:    PCT/GB2006/001635
Publication Date: 09.11.2006 International Filing Date: 04.05.2006
IPC:
A61K 47/48 (2006.01)
Applicants: CHROMA THERAPEUTICS LTD [GB/GB]; 93 Milton Park, Abingdon, Oxfordshire OX14 4RY (GB) (For All Designated States Except US).
DAVIDSON, Alan, Hornsby [GB/GB]; (GB) (For US Only).
DRUMMOND, Alan, Hastings [GB/GB]; (GB) (For US Only).
NEEDHAM, Lindsey, Ann [GB/GB]; (GB) (For US Only)
Inventors: DAVIDSON, Alan, Hornsby; (GB).
DRUMMOND, Alan, Hastings; (GB).
NEEDHAM, Lindsey, Ann; (GB)
Agent: WALLS, Alan, James; PO Box 223, Tadworth, Surrey KT20 5YF (GB)
Priority Data:
0509226.7 05.05.2005 GB
60/680,542 13.05.2005 US
Title (EN) ALPHA AMINOACID ESTER-DRUG CONJUGATES HYDROLYSABLE BY CARBOXYLESTERASE
(FR) MODULATION D'ENZYME ET DE RECEPTEUR
Abstract: front page image
(EN)Covalent conjugation of an alpha amino acid ester to a modulator of the activity of a target intracellular enzyme or receptor, wherein the ester group of the conjugate is hydrolysable by one or more intracellular carboxylesterase enzymes to the corresponding acid, leads to accumulation of the carboxylic acid hydrolysis product in the cell and enables improved or more prolonged enzyme or receptor modulation relative to the unconjugated modulator.
(FR)L'invention porte sur la conjugaison covalente d'un ester d'acide aminé alpha et d'un modulateur de l'activité d'une enzyme ou d'un récepteur intracellulaire cible, le groupe ester du conjugué étant hydrolysable par une ou plusieurs enzymes carboxylestérases intracellulaires à l'acide correspondant, qui mène à une accumulation du produit de l'hydrolyse de l'acide carboxylique dans la cellule et permet une modulation de l'enzyme ou du récepteur améliorée ou prolongée par rapport au modulateur non conjugué.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)