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1. (WO2006117565) GLUCAGON-LIKE-PEPTIDE-2 (GLP-2) ANALOGUES

Pub. No.:    WO/2006/117565    International Application No.:    PCT/GB2006/001633
Publication Date: Nov 9, 2006 International Filing Date: May 4, 2006
IPC: C07K 14/605
A61K 38/26
Applicants: ZEALAND PHARMA A/S
LARSEN, Bjarne, Due
PETERSEN, Yvette, Miata
EBBEHØJ, Kirsten
Inventors: LARSEN, Bjarne, Due
PETERSEN, Yvette, Miata
EBBEHØJ, Kirsten
Title: GLUCAGON-LIKE-PEPTIDE-2 (GLP-2) ANALOGUES
Abstract:
GLP-2 analogues are disclosed which comprise one of more substitutions as compared to [hGly2]GLP-2 and which improved biological activity in vivo and/or improved chemical stability, e.g. as assessed in in vitro stability assays. More particularly, preferred GLP-2 analogues disclosed herein comprise substitutions at one or more of positions 8, 16, 24 and/or 28 of the wild-type GLP-2 sequence, optionally in combination with further substitutions at position 2 (as mentioned in the introduction) and one or more of positions 3, 5, 7, 10 and 11, and/or a deletion of one or more of amino acids 31 to 33 and/or the addition of a N-terminal or C-terminal stabilizing peptide sequence. The analogues are particularly useful for the prophylaxis or treatment of stomach and bowel-related disorders and for ameliorating side effects of chemotherapy.