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1. WO2006116905 - MEDICINAL COMPOUNDS AS ANTAGONISTS OF THE PLATELET- ACTIVATING FACTOR RECEPTOR

Publication Number WO/2006/116905
Publication Date 09.11.2006
International Application No. PCT/CN2005/002390
International Filing Date 30.12.2005
IPC
C07D 493/22 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
493Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
22in which the condensed system contains four or more hetero rings
C07D 307/00 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
307Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
A61P 7/02 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
7Drugs for disorders of the blood or the extracellular fluid
02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
CPC
A61P 7/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
7Drugs for disorders of the blood or the extracellular fluid
02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
C07D 493/22
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
493Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
22in which the condensed system contains four or more hetero rings
Applicants
  • 秦引林 QIN, Yinlin [CN]/[CN]
  • 夏鹏 XIA, Peng [CN]/[CN] (UsOnly)
  • 张倩 ZHANG, Qian [CN]/[CN] (UsOnly)
  • 陈瑛 CHEN, Ying [CN]/[CN] (UsOnly)
  • 何龙其 HE, Longqi [CN]/[CN] (UsOnly)
Inventors
  • 秦引林 QIN, Yinlin
  • 夏鹏 XIA, Peng
  • 张倩 ZHANG, Qian
  • 陈瑛 CHEN, Ying
  • 何龙其 HE, Longqi
Agents
  • 南京经纬专利商标代理有限公司 NANJING JINGWEI PATENT & TRADEMARK AGENCY CO., LTD.
Priority Data
200510039158.029.04.2005CN
200510041060.918.07.2005CN
Publication Language Chinese (zh)
Filing Language Chinese (ZH)
Designated States
Title
(EN) MEDICINAL COMPOUNDS AS ANTAGONISTS OF THE PLATELET- ACTIVATING FACTOR RECEPTOR
(FR) COMPOSES THERAPEUTIQUES EN TANT QU'ANTAGONISTES DU RECEPTEUR DU FACTEUR D'ACTIVATION DES PLAQUETTES
(ZH) 抗血小板活化因子的药物化合物
Abstract
(EN) The invention discloses medicinal compounds as antagonists of the platelet-activating factor receptor with a nitrogen-containing group linked to the 10-hydroxyl of ginkgolide B. The invention compounds have improved water-solubility, bioavailability and therapeutic effect. Especially, the water-solubility, bioavailability and therapeutic effect of the salts of the compounds have been improved remarkably.
(FR) La présente invention concerne des composés thérapeutiques employés en tant qu'antagonistes du récepteur du facteur d'activation des plaquettes, lesdits composés comportant un groupement azoté lié à l'hydroxyle en position 10 du ginkgolide B. Les composés selon l'invention présentent une augmentation des caractéristiques de solubilité dans l'eau, de biodisponibilité et d'effet thérapeutique. En particulier, la solubilité dans l'eau, la biodisponibilité et l'effet thérapeutique des sels desdits composés ont été remarquablement améliorés.
(ZH) 本发明公开了一种抗血小板活化因子的药物化合物,该药物化合物是在银杏内酯B的10位羟基上连接有含氮基团。本发明具有改善了水溶性,提高生物利用度,增强疗效;尤其是在其成盐后,其水溶性、生物利用度及疗效均有大幅度提高和增强等优点。
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