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1. (WO2006116681) TAT-003 AND METHODS OF ASSESSING AND TREATING CANCER
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/116681    International Application No.:    PCT/US2006/016242
Publication Date: 02.11.2006 International Filing Date: 28.04.2006
IPC:
G01N 33/53 (2006.01), C07K 14/00 (2006.01)
Applicants: CAPRION PHARMACEUTICALS, INC. [CA/CA]; 7150 Alexander-fleming, Montreal, Quebec H4S 2C8 (CA) (For All Designated States Except US).
HU, Michael [CA/US]; (US) (For US Only).
TSANG, John [CA/US]; (US) (For US Only).
JAITLY, Navdeep [CA/US]; (US) (For US Only).
SWAMY, Sajani [CA/GB]; (GB) (For US Only).
HAMAIDI, Lyes [CA/CA]; (CA) (For US Only).
FILGUEIRA, Marcelo [CA/CA]; (CA) (For US Only).
CHELSKY, Daniel [US/CA]; (CA) (For US Only).
LANOIX, Joel [CA/CA]; (CA) (For US Only).
ENG, Kevin [CA/CA]; (CA) (For US Only).
THIBAULT, Pierre [CA/CA]; (CA) (For US Only).
FAUBERT, Denis [CA/CA]; (CA) (For US Only).
BRUNET, Sylvain [CU/CA]; (CA) (For US Only).
OSTERMANN, Joachim [DE/CA]; (CA) (For US Only).
BOULOS, Marguerite [CA/CA]; (CA) (For US Only).
KEARNEY, Paul [CA/CA]; (CA) (For US Only).
BUTLER, Heather [GB/CA]; (CA) (For US Only)
Inventors: HU, Michael; (US).
TSANG, John; (US).
JAITLY, Navdeep; (US).
SWAMY, Sajani; (GB).
HAMAIDI, Lyes; (CA).
FILGUEIRA, Marcelo; (CA).
CHELSKY, Daniel; (CA).
LANOIX, Joel; (CA).
ENG, Kevin; (CA).
THIBAULT, Pierre; (CA).
FAUBERT, Denis; (CA).
BRUNET, Sylvain; (CA).
OSTERMANN, Joachim; (CA).
BOULOS, Marguerite; (CA).
KEARNEY, Paul; (CA).
BUTLER, Heather; (CA)
Agent: ELBING, Karen; CLARK & ELBING LLP, 101 Federal Street, Boston, Massachusetts 02110 (US)
Priority Data:
60/675,603 28.04.2005 US
Title (EN) TAT-003 AND METHODS OF ASSESSING AND TREATING CANCER
(FR) TAT-003 ET PROCEDES DE DETERMINATION ET DE TRAITEMENT DU CANCER
Abstract: front page image
(EN)Surprisingly, the present inventors have discovered that expression of TAT-003 protein in human patients is associated with cancer, and that the over-expressed protein is present in plasma membrane fractions. Thus, the present inventors have discovered that TAT-003 is associated with abnormal development and growth, and may be useful as a target for the identification of anti-cancer compounds, including antibodies for use in immunotherapy. Accordingly, the present invention provides methods for the identification of compounds that inhibit TAT-003 expression or activity, comprising: contacting a candidate compound with a TAT-003 and detecting the presence or absence of binding between said compound and said TAT-003, or detecting a change in TAT-003 expression or activity. Methods are also included for the identification of compounds that modulate TAT-003 expression or activity, comprising: administering a compound to a cell or cell population, and detecting a change in TAT-003 expression or activity. The methods of the invention are useful for the identification of anti-cancer compounds.
(FR)De manière surprenante, les inventeurs de la présente invention ont découvert que l'expression de la protéine TAT-003 chez les patients humains est liée au cancer et que la protéine sur-exprimée est présente dans les fractions de membranes plasmiques. Ainsi les inventeurs ont découvert que la protéine TAT-003 est liée au développement et à la croissance anormaux et qu'elle s'avère utile comme une cible de l'identification de composés anti-cancer, y compris les anticorps à utiliser en immunothérapie. En conséquence, la présente invention concerne des procédés d'identification de composés qui inhibent l'expression ou l'activité de la TAT-003 et consistent à mettre en contact un composé candidat avec une TAT-003 et à détecter la présence ou l'absence de liaison entre ce composé et cette TAT-003, ou à détecter un changement de l'expression ou de l'activité de la TAT-003. L'invention concerne également des procédés d'identification de composés qui modulent l'expression ou l'activité de la TAT-003 et consistent à administrer un composé à une cellule ou une population de cellules et à détecter un changement dans l'expression ou l'activité de la TAT-003. Ces procédés de l'invention s'avèrent utiles pour l'identification de composés anti-cancer.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)