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1. (WO2006116602) MARKERS ASSOCIATED WITH THE THERAPEUTIC EFFICACY OF GLATIRAMER ACETATE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/116602    International Application No.:    PCT/US2006/016036
Publication Date: 02.11.2006 International Filing Date: 24.04.2006
IPC:
C07H 21/04 (2006.01), C12Q 1/68 (2006.01)
Applicants: YEDA RESEARCH AND DEVELOPMENT COMPANY [IL/IL]; P.O. Box 95, -, 76100 Rehovot (IL) (For All Designated States Except US).
TEVA PHARMACEUTICAL INDUSTRIES, LTD. [IL/IL]; 5 Basel Street, -, 49131 Petach Tikva (IL) (For All Designated States Except US).
RAPPAPORT FACULTY OF MEDICINE AND RESEARCH INSTITUTE [IL/IL]; Carmel Medical Center, -, 34362 Haifa (IL) (For All Designated States Except US).
TEVA PHARMACEUTICALS USA, INC. [US/US]; 425 Privet Road, PO Box 1005, Horsham, Pennsylvania 19044-8005 (US) (BB only).
LANCET, Doron [IL/IL]; (IL) (For US Only).
BECKMANN, Jacques [IL/IL]; (IL) (For US Only).
AVIDAN, Nili [IL/IL]; (IL) (For US Only).
BEN-ASHER, Edna [IL/IL]; (IL) (For US Only).
GOLDSTAUB, Dan [IL/IL]; (IL) (For US Only).
HAYARDENY, Liat [IL/IL]; (IL) (For US Only).
GROSSMAN, Iris [IL/IL]; (IL) (For US Only).
MILLER, Ariel [IL/IL]; (IL) (For US Only).
SINGER, Clara [IL/IL]; (IL) (For US Only)
Inventors: LANCET, Doron; (IL).
BECKMANN, Jacques; (IL).
AVIDAN, Nili; (IL).
BEN-ASHER, Edna; (IL).
GOLDSTAUB, Dan; (IL).
HAYARDENY, Liat; (IL).
GROSSMAN, Iris; (IL).
MILLER, Ariel; (IL).
SINGER, Clara; (IL)
Agent: HILL, Laurie, L.; Morrison & Foerster LLP, 12531 High Bluff Drive, Suite 100, San Diego, California 92130 (US)
Priority Data:
60/674,545 25.04.2005 US
Title (EN) MARKERS ASSOCIATED WITH THE THERAPEUTIC EFFICACY OF GLATIRAMER ACETATE
(FR) MARQUEURS ASSOCIES A L'EFFICACITE THERAPEUTIQUE D'ACETATE DE GLATIRAMERE
Abstract: front page image
(EN)The present invention is directed to methods and kits based, at least in part, on the identification of allele-specific responsiveness or non-responsiveness to glatiramer acetate for the treatment of immune disorders, such as relapsing-remitting multiple sclerosis. The allele-specific responsiveness or non-responsiveness is based on polymorphisms in the following genes, CTSS, MBP, TCRB, CD95, CD86, IL-1R1, CD80, SCYA5, MMP9, MOG, SPPl and IL-12RB2.
(FR)La présente invention concerne des procédés et des kits basés, au moins en partie, sur l'identification de la sensibilité ou non sensibilité allèle-spécifique à l'acétate de glatiramère pour le traitement de troubles de l'immunité tels que la sclérose en plaques cyclique. La sensibilité ou non sensibilité allèle-spécifique à l'acétate de glatiramère se base sur des polymorphismes des gènes suivants: CTSS, MBP, TCRB, CD95, CD86, IL-1R1, CD80, SCYA5, MMP9, MOG, SPPl et IL-12RB2.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)