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Machine translation
1. (WO2006116503) METHODS AND COMPOSITIONS FOR MODULATING WNT SIGNALING PATHWAY
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/116503    International Application No.:    PCT/US2006/015821
Publication Date: 02.11.2006 International Filing Date: 26.04.2006
IPC:
C12Q 1/68 (2006.01), G01N 33/50 (2006.01)
Applicants: IRM LLC [--/--]; Hurst Holme, 12 Trott Road, Hamilton, HM 11 (BM) (For All Designated States Except US).
THE SCRIPPS RESEARCH INSTITUTE [US/US]; 10550 North Torrey Pines Road, La Jolla, California 92037 (US) (For All Designated States Except US).
ZHANG, Qisheng [CN/US]; (US) (For US Only).
DING, Sheng [CN/US]; (US) (For US Only).
SCHULTZ, Peter G. [US/US]; (US) (For US Only)
Inventors: ZHANG, Qisheng; (US).
DING, Sheng; (US).
SCHULTZ, Peter G.; (US)
Agent: WANG, Hugh; Genomics Institute Of The Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, California 92121 (US)
Priority Data:
60/675,301 26.04.2005 US
Title (EN) METHODS AND COMPOSITIONS FOR MODULATING WNT SIGNALING PATHWAY
(FR) METHODES ET COMPOSITIONS DE MODULATION DE LA VOIE DE SIGNALISATION WNT
Abstract: front page image
(EN)This invention provides novel Wnt signaling pathway regulators. The invention also provides methods of using the Wnt signaling pathway regulators to screen for compounds that modulate Wnt signaling pathway. The methods comprise first screening test compounds for modulators of a Wnt signaling pathway regulator disclosed herein, and then further screening the identified modulating agents for ability to modulate Wnt signaling pathway. The invention further provides methods for modulating Wnt signaling pathway and pharmaceutical compositions for treating diseases and conditions (e.g., tumors) associated with abnormal Wnt signaling activities.
(FR)L'invention concerne des nouveaux régulateurs de la voie de signalisation Wnt. Elle porte également sur des méthodes d'utilisation desdits régulateurs de voie de signalisation Wnt pour l'analyse de composés qui modulent la voie de signalisation Wnt. Cette méthode consiste à d'abord analyser par criblage les composés d'essai à la recherche des modulateurs d'un régulateur de voie de signalisation Wnt décrit ici, et à rechercher par criblage les agents de modulation identifiés aptes à moduler la voie de signalisation Wnt. L'invention porte également sur des méthodes de modulation de la voie de signalisation Wnt et sur des compositions pharmaceutiques pour le traitement de maladies et états (ex.tumeurs) associés à des activités de signalisation Wnt anormales.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)