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1. (WO2006116475) IMMUNOSTIMULATORY COMPOSITIONS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/116475    International Application No.:    PCT/US2006/015772
Publication Date: 02.11.2006 International Filing Date: 25.04.2006
IPC:
A61K 39/395 (2006.01), C07K 16/46 (2006.01)
Applicants: 3M INNOVATIVE PROPERTIES COMPANY [US/US]; 3M Center, P.O. Box 33427, Saint Paul, MN 55133-3427 (US) (For All Designated States Except US).
GRIESGRABER, George, W. [US/US]; (US) (For US Only).
KIEPER, William, C. [US/US]; (US) (For US Only).
MENDOZA, James, D. [US/US]; (US) (For US Only).
GRAM, Christopher, D. [US/US]; (US) (For US Only)
Inventors: GRIESGRABER, George, W.; (US).
KIEPER, William, C.; (US).
MENDOZA, James, D.; (US).
GRAM, Christopher, D.; (US)
Agent: GRAM, Christopher, D.; 3M Center, P.O. Box 33427, Saint Paul, MN 55133-3427 (US)
Priority Data:
60/674,753 25.04.2005 US
Title (EN) IMMUNOSTIMULATORY COMPOSITIONS
(FR) COMPOSITIONS IMMUNOSTIMULANTES
Abstract: front page image
(EN)The present invention provides immunostimulatory compositions. Generally, the immunostimulatory compositions include at least partially purified conjugates that include at least one IRM moiety covalently coupled to an antigenic peptide. In some embodiments, the immunostimulatory composition includes monomeric conjugates. In other embodiments, the immunostimulatory composition includes an aggregate of a conjugate and at least one other antigenic peptide (e.g., another conjugate and/or unconjugated peptide). The present invention also provides methods of using such immunostimulatory compositions. In some embodiments, the methods include inducing an immune response by contacting the immunostimulatory composition with an immune cell. In other embodiments, the method includes treating a condition by administering an immunostimulatory composition to a subject in an amount effective to ameliorate at least one symptom or clinical sign of the condition.
(FR)La présente invention concerne des compositions immunostimulantes. En règle générale, ces compositions immunostimulantes comprennent des conjugués au moins partiellement purifiés contenant au moins une fraction de modificateur de réponse immunitaire (IRM) couplée par covalence à un peptide antigénique. Dans certains modes de réalisation, la composition immunostimulante comprend des conjugués monomères. Dans d'autres modes de réalisation, la composition immunostimulante comprend un agrégat composé d'un conjugué et d'au moins un autre peptide antigénique (un autre peptide conjugué et/ou non conjugué, par exemple). La présente invention concerne également des méthodes destinées à l'utilisation de ces compositions immunostimulantes. Dans certains modes de réalisation, ces méthodes consistent à induire une réponse immunitaire en mettant la composition immunostimulante en contact avec une cellule immunitaire. Dans d'autres modes de réalisation, la méthode consiste à traiter un trouble en administrant une composition immunostimulante à un sujet en quantité suffisante pour traiter au moins un symptôme ou signe clinique du trouble.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)