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1. WO2006116107 - IMMUNOLIPOSOME COMPOSITION FOR TARGETING TO A HER2 CELL RECEPTOR

Publication Number WO/2006/116107
Publication Date 02.11.2006
International Application No. PCT/US2006/015122
International Filing Date 20.04.2006
IPC
A61K 9/127 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
10Dispersions; Emulsions
127Liposomes
A61K 47/48 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
48the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
A61P 35/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
CPC
A61K 39/395
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies
A61K 47/50
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
A61K 47/6855
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
68the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
6835the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
6851the antibody targeting a determinant of a tumour cell
6855the tumour determinant being from breast cancer cell
A61K 47/6913
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
69the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
6905the form being a colloid or an emulsion
6911the form being a liposome
6913the liposome being modified on its surface by an antibody
A61K 9/127
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
10Dispersions; Emulsions
127Liposomes
A61K 9/1271
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
10Dispersions; Emulsions
127Liposomes
1271Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
Applicants
  • ALZA CORPORATION [US]/[US] (AllExceptUS)
  • HJORTSVANG, Kristen [US]/[US] (UsOnly)
  • GUO, Luke [US]/[US] (UsOnly)
  • WONG, Francis, M. P. [CA]/[US] (UsOnly)
  • NAJAFI, Azar [US]/[US] (UsOnly)
  • HUANG, Anthony [US]/[US] (UsOnly)
  • ABRA, Robert [US]/[US] (UsOnly)
  • KELLEY, Laura [US]/[US] (UsOnly)
Inventors
  • HJORTSVANG, Kristen
  • GUO, Luke
  • WONG, Francis, M. P.
  • NAJAFI, Azar
  • HUANG, Anthony
  • ABRA, Robert
  • KELLEY, Laura
Agents
  • MOHR, Judy, M.
Priority Data
60/674,02922.04.2005US
60/736,66914.11.2005US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) IMMUNOLIPOSOME COMPOSITION FOR TARGETING TO A HER2 CELL RECEPTOR
(FR) COMPOSITION D'IMMUNOLIPOSOMES DESTINEE AU CIBLAGE D'UN RECEPTEUR DES CELLULES HER2
Abstract
(EN)
An immunoliposome composition comprised of liposomes bearing a ligand for targeting to cells expressing a growth factor receptor, such as HER2, is described. Binding of the immunoliposome to HER2-expressing cells results in internalization of the immunoliposome for cytoplasmic delivery of an entrapped drug.
(FR)
L'invention concerne une composition d'immunoliposomes constituée de liposomes portant un ligand de ciblage de cellules exprimant un récepteur de facteur de croissance, tel que HER2. La liaison de l'immunoliposome aux cellules exprimant HER2 entraîne l'internalisation de l'immunoliposome pour la libération cytoplasmique d'un médicament piégé.
Latest bibliographic data on file with the International Bureau