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1. WO2006116005 - STABILIZATION OF CARDIAC TROPONIN

Publication Number WO/2006/116005
Publication Date 02.11.2006
International Application No. PCT/US2006/014958
International Filing Date 20.04.2006
IPC
C07K 14/47 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
47from mammals
G01N 33/50 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
CPC
C07K 14/4716
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
47from mammals
4701not used
4716Muscle proteins, e.g. myosin, actin
G01N 2800/324
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2800Detection or diagnosis of diseases
32Cardiovascular disorders
324Coronary artery diseases, e.g. angina pectoris, myocardial infarction
G01N 33/6887
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68involving proteins, peptides or amino acids
6887from muscle, cartilage or connective tissue
Applicants
  • ABBOTT LABORATORIES [US]/[US] (AllExceptUS)
  • LAIRD, Don, M. [US]/[US] (UsOnly)
  • YOUNG, Charles, E. [US]/[US] (UsOnly)
Inventors
  • LAIRD, Don, M.
  • YOUNG, Charles, E.
Agents
  • SCHODIN, David, J.
Priority Data
60/675,54228.04.2005US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) STABILIZATION OF CARDIAC TROPONIN
(FR) STABILISATION DE LA TROPONINE CARDIAQUE
Abstract
(EN)
The present invention relates to a troponin protein or complex of two troponin proteins stabilized in a matrix containing at least one anionic surfactant. The stabilized troponin or complex of troponin proteins is used as a control or calibration standard in assays for the determination of blood levels of troponin in patient samples that are expect to exhibit elevated levels of cardiac proteins. The troponin protein or complex of troponin proteins remains stabilized at room temperatures for at least six (6) months.
(FR)
La présente invention concerne une protéine de type troponine ou un complexe de deux protéines de type troponines stabilisé(e) dans une matrice contenant au moins un tensioactif anionique. La protéine de type troponine stabilisée ou le complexe de protéines de type troponines stabilisé est utilisé(e) comme étalon de contrôle ou référence d'étalonnage dans des dosages permettant de déterminer des concentrations sanguines de troponine dans des prélèvements de patients supposés présenter des niveaux de protéines cardiaques élevés. A température ambiante, la protéine de type troponine ou le complexe de protéines de type troponines reste stable pendant au moins six (6) mois.
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