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1. WO2006115297 - METHOD FOR EVALUATING COMPOUND USING BARLP AND SUBSTANCE FOR SUPPRESSING EATING AND BODY WEIGHT

Publication Number WO/2006/115297
Publication Date 02.11.2006
International Application No. PCT/JP2006/309122
International Filing Date 25.04.2006
IPC
C12Q 1/02 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
02involving viable microorganisms
A61K 45/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45Medicinal preparations containing active ingredients not provided for in groups A61K31/-A61K41/132
A61P 3/04 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
04Anorexiants; Antiobesity agents
C12N 15/09 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
C12Q 1/68 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
CPC
A61P 3/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
04Anorexiants; Antiobesity agents
A61P 43/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
C12Q 1/6883
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6883for diseases caused by alterations of genetic material
C12Q 2600/136
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
2600Oligonucleotides characterized by their use
136Screening for pharmacological compounds
C12Q 2600/158
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
2600Oligonucleotides characterized by their use
158Expression markers
G01N 2333/72
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2333Assays involving biological materials from specific organisms or of a specific nature
435from animals; from humans
705Assays involving receptors, cell surface antigens or cell surface determinants
72for hormones
Applicants
  • 萬有製薬株式会社 BANYU PHARMACEUTICAL CO., LTD. [JP]/[JP] (AllExceptUS)
  • 南部 宏英 NAMBU, Hirohide [JP]/[JP] (UsOnly)
  • 尾崎 諭司 OZAKI, Satoshi [JP]/[JP] (UsOnly)
  • 田中 岳 TANAKA, Takeshi [JP]/[JP] (UsOnly)
  • 太田 尚 OHTA, Hisashi [JP]/[JP] (UsOnly)
Inventors
  • 南部 宏英 NAMBU, Hirohide
  • 尾崎 諭司 OZAKI, Satoshi
  • 田中 岳 TANAKA, Takeshi
  • 太田 尚 OHTA, Hisashi
Common Representative
  • 萬有製薬株式会社 BANYU PHARMACEUTICAL CO., LTD.
Priority Data
2005-12777226.04.2005JP
Publication Language Japanese (ja)
Filing Language Japanese (JA)
Designated States
Title
(EN) METHOD FOR EVALUATING COMPOUND USING BARLP AND SUBSTANCE FOR SUPPRESSING EATING AND BODY WEIGHT
(FR) PROCEDE PERMETTANT D’EVALUER UN COMPOSE UTILISANT LE BARLP ET SUBSTANCE PERMETTANT DE COUPER LA FAIM ET DE REDUIRE LE POIDS CORPOREL
(JA) BARLPを用いた化合物の評価方法及び摂食・体重抑制物質
Abstract
(EN) It is intended to provide a method for evaluating a compound which regulates eating or body weight characterized by comprising the steps of introducing a BARLP gene and preparing a cell expressing BARLP; bringing a test compound into contact with the cell; and detecting a specific binding of the test compound to the BARLP and a method for evaluating a compound further comprising the step of evaluating a test compound using a nonhuman genetically-engineered animal in which the BARLP gene is inactivated. According to this invention, knowledge about a relationship between BARLP and biological functions is obtained and a method for evaluating a compound targeting BARLP and a BARLP ligand obtained by the evaluation can be provided.
(FR) L’invention concerne un procédé permettant d’évaluer un composé qui régule la faim ou le poids corporel Cette méthode se caractérise par les étapes suivantes : l’introduction d’un gène BARLP et la préparation d’une cellule exprimant le BARLP ; la mise en contact d’un composé test avec la cellule ; et la détection d’une liaison spécifique du composé test au BARLP. L’invention concerne également un procédé permettant d’évaluer un composé, qui comprend aussi l’étape consistant à évaluer un composé test à l’aide d’un animal non humain génétiquement modifié dans lequel le gène BARLP a été inactivé. Cette invention permet d’obtenir des informations sur le lien existant entre le BARLP et des fonctions biologiques, un procédé permettant d’évaluer un composé ciblant le BARLP, ainsi qu’un ligand BARLP obtenu à la suite de l’évaluation.
(JA) 本発明は、摂食又は体重を制御する化合物の評価方法であって、BARLP遺伝子を導入し、BARLPを発現する細胞を調製する工程と、該細胞に被検化合物を接触させる工程と、該BARLPに対する該被検化合物の特異的結合を検出する工程と、を含むことを特徴とする化合物の評価方法、及び、BARLP遺伝子が不活性化されている非ヒト遺伝子改変動物を用いて被検化合物の評価を行う工程をさらに含む化合物の評価方法を提供する。かかる発明により、BARLPと生体機能との関連について知見を得、BARLPを標的とした化合物の評価方法や当該評価によって得られたBARLPのリガンドを提供することが可能となる。
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