WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2006115295) COMPOSITIONS AND METHODS FOR TREATING HEMOSTASIS DISORDERS ASSOCIATED WITH CLEC-2 SIGNAL TRANSDUCTION
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/115295    International Application No.:    PCT/JP2006/309066
Publication Date: 02.11.2006 International Filing Date: 24.04.2006
IPC:
C12Q 1/02 (2006.01), A61K 38/00 (2006.01), A61K 39/395 (2006.01), A61K 45/00 (2006.01), A61P 9/10 (2006.01)
Applicants: UNIVERSITY OF YAMANASHI [JP/JP]; 4-37, Takeda 4-chome, Kofu-shi, Yamanashi, 4008510 (JP) (For All Designated States Except US).
OZAKI, Yukio [JP/JP]; (JP) (For US Only).
INOUE, Katsue [JP/JP]; (JP) (For US Only).
WATSON, Steve, P. [GB/GB]; (GB) (For US Only)
Inventors: OZAKI, Yukio; (JP).
INOUE, Katsue; (JP).
WATSON, Steve, P.; (GB)
Agent: ISHIKAWA, Hidetake; 26-1-114, Higashi-yurigaoka 3-chome, Asao-ku, Kawasaki-shi, Kanagawa, 2150012, (JP)
Priority Data:
60/674,287 25.04.2005 US
Title (EN) COMPOSITIONS AND METHODS FOR TREATING HEMOSTASIS DISORDERS ASSOCIATED WITH CLEC-2 SIGNAL TRANSDUCTION
(FR) COMPOSITIONS ET METHODES DE TRAITEMENT DE TROUBLES HEMOSTATIQUES ASSOCIES A LA TRANSDUCTION DU SIGNAL DU CLEC-2
Abstract: front page image
(EN)The present invention provides a method for screening compounds to identify therapeutic candidates for treating hemostasis disorders, the method includes the steps of contacting a cell that expresses a CLEC-2 receptor with a test compound and a CLEC-2 receptor ligand, under conditions which, but for the presence of the test compound, permit binding of the CLEC-2 receptor to the CLEC-2 receptor ligand; and detecting if any increase or decrease in an indicator of CLEC-2 receptor activity is observed in comparison to a control; wherein an increase or decrease in the indicator in comparison to the control indicates that the test compound is a candidate for modulating hemostasis.
(FR)L'invention porte sur une méthode de criblage de composés en vue de l'identification de candidats au traitement de troubles hémostatiques. Ladite méthode comporte les étapes suivantes: mise en contact d'une cellule exprimant un récepteur CLEC-2, avec un composé à tester et un ligand du récepteur CLEC-2 dans des conditions qui, en l'absence du composé à tester, permettent la fixation du récepteur CLEC-2 à son ligand; et détection de toute augmentation ou diminution d'un indicateur de l'activité du récepteur CLEC-2 par rapport à une référence, une telle augmentation ou diminution indiquant que le composé à tester est un candidat modulateur de l'hémostase.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)