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1. (WO2006115279) COMPOSITION FOR PRESERVATION OF VASCULAR ENDOTHELIUM
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/115279    International Application No.:    PCT/JP2006/308788
Publication Date: 02.11.2006 International Filing Date: 20.04.2006
Chapter 2 Demand Filed:    31.10.2006    
IPC:
A61K 48/00 (2006.01), A61K 31/7088 (2006.01), A61L 31/00 (2006.01), A61P 9/10 (2006.01), A61P 43/00 (2006.01)
Applicants: NIHON UNIVERSITY [JP/JP]; 8-24, Kudan-Minami 4-chome Chiyoda-ku, Tokyo 1028275 (JP) (For All Designated States Except US).
Gentier Biosystems, Inc. [JP/JP]; Nihon University Bekkan 2F 2, Goban-cho, Chiyoda-ku Tokyo 1020076 (JP) (For All Designated States Except US).
FUKUDA, Noboru [JP/JP]; (JP) (For US Only)
Inventors: FUKUDA, Noboru; (JP)
Agent: ISHII, Yoshio; Toranomon Nakata Bldg., 4F 7-7, Toranomon 2-chome Minato-ku, Tokyo 1050001 (JP)
Priority Data:
2005-123457 21.04.2005 JP
Title (EN) COMPOSITION FOR PRESERVATION OF VASCULAR ENDOTHELIUM
(FR) COMPOSITION POUR LA PRESERVATION DE L'ENDOTHELIUM VASCULAIRE
(JA) 血管内皮温存化組成物
Abstract: front page image
(EN)Disclosed is a composition for the preservation of a vascular endothelium which can prevent coronary restenosis and can preserve a vascular endothelium. The composition comprises a PDGF A-chain antisense oligonucleotide or a derivative thereof as the active ingredient. The composition can inhibit the abnormal growth of vascular smooth muscle cells and preserve a vascular endothelium.
(FR)L'invention concerne une composition pour la préservation de l'endothélium vasculaire qui permet de prévenir la resténose coronaire et de préserver l'endothélium vasculaire. La composition comprend un oligonucléotide antisens à chaîne A PDGF ou un dérivé de ce dernier en tant que principe actif. La composition selon l'invention permet d'inhiber la croissance anormale des cellules du muscle lisse de la paroi vasculaire et de préserver l'endothélium vasculaire.
(JA) 冠動脈再狭窄を予防し、血管内の内皮を温存できる血管内皮温存化組成物の提供。 PDGF−A鎖のアンチセンスオリゴヌクレオチド又はその誘導体を有効成分とする血管内皮温存を用いることで、血管平滑筋細胞の異常な増殖を抑制し、血管内の内皮を温存することができる。
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)