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Pub. No.:    WO/2006/115188    International Application No.:    PCT/JP2006/308387
Publication Date: 02.11.2006 International Filing Date: 21.04.2006
C07D 413/14 (2006.01), A61K 31/42 (2006.01), A61K 31/4245 (2006.01), A61K 31/4439 (2006.01), A61P 1/04 (2006.01), A61P 1/16 (2006.01), A61P 3/10 (2006.01), A61P 7/06 (2006.01), A61P 9/00 (2006.01), A61P 9/04 (2006.01), A61P 9/06 (2006.01), A61P 9/10 (2006.01), A61P 9/12 (2006.01), A61P 11/00 (2006.01), A61P 11/06 (2006.01), A61P 13/10 (2006.01), A61P 13/12 (2006.01), A61P 17/00 (2006.01), A61P 17/02 (2006.01), A61P 17/06 (2006.01), A61P 17/16 (2006.01), A61P 19/02 (2006.01), A61P 19/04 (2006.01), A61P 21/00 (2006.01), A61P 21/04 (2006.01), A61P 25/00 (2006.01), A61P 25/08 (2006.01), A61P 25/14 (2006.01), A61P 25/16 (2006.01), A61P 25/18 (2006.01), A61P 25/24 (2006.01), A61P 25/28 (2006.01), A61P 27/02 (2006.01), A61P 29/00 (2006.01), A61P 31/10 (2006.01), A61P 31/12 (2006.01), A61P 33/02 (2006.01), A61P 35/00 (2006.01), A61P 35/02 (2006.01), A61P 37/02 (2006.01), A61P 37/06 (2006.01), A61P 37/08 (2006.01)
Applicants: DAIICHI SANKYO COMPANY, LIMITED [JP/JP]; 3-5-1, Nihonbashi Honcho, Chuo-ku, Tokyo 103-8426 (JP) (For All Designated States Except US).
NISHI, Takahide; (For US Only).
NAKAMURA, Tsuyoshi; (For US Only).
SEKIGUCHI, Yukiko; (For US Only).
MIZUNO, Yumiko; (For US Only).
SHIMOZATO, Takaichi; (For US Only).
NARA, Futoshi; (For US Only)
Inventors: NISHI, Takahide; .
NAKAMURA, Tsuyoshi; .
SEKIGUCHI, Yukiko; .
MIZUNO, Yumiko; .
SHIMOZATO, Takaichi; .
NARA, Futoshi;
Agent: YAGUCHI, Toshiaki; c/o DAIICHI SANKYO COMPANY, LIMITED 1-16-13, Kitakasai Edogawa-ku, Tokyo 134-8630 (JP)
Priority Data:
2005-124353 22.04.2005 JP
(JA) ヘテロ環化合物
Abstract: front page image
(EN)Disclosed is a novel low toxic compound having an excellent immunosuppressive action or a pharmacologically acceptable salt thereof. Specifically disclosed is a compound represented by the general formula (I) below, a pharmacologically acceptable salt thereof or a pharmacologically acceptable prodrug thereof. (I) (In the formula, A represents a carboxyl group or the like; B represents a hydrogen atom or the like; V represents a single bond, a methylene group or the like; n represents an integer of 0-2; W represents a 5- to 7-membered heterocyclic group or the like; and Z represents a group or the like selected from a substituent group A consisting of halogen atoms, C1-C6 alkyl groups, C3-C7 cycloalkyl groups and the like.)
(FR)L'invention concerne un nouveau composé faiblement toxique, ayant une excellente action immunosuppressive, ou un de ses sels pharmaceutiquement acceptables. L'invention concerne notamment un composé représenté par la formule générale (I) ci-dessous, ou un de ses sels ou promédicaments pharmaceutiquement acceptables. (I) (Dans la formule, A représente un groupe carboxyle ou similaires ; B représente un atome d'hydrogène ou similaires ; V représente une liaison simple, un groupe méthylène ou similaires ; n représente un entier entre 0 et 2 ; W représente un groupe hétérocyclique à 5 à 7 chaînons ou similaires ; et Z représente un groupe ou similaires choisi parmi ou groupe substituant A consistant en des atomes d'halogène, des groupes alkyle en C1-C6, des groupes cycloalkyle en C3-C7 et similaires).
(JA)not available
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)