Processing

Please wait...

Settings

Settings

Goto Application

1. WO2006115140 - PREVENTIVE OR REMEDY FOR BOWEL DISEASE

Publication Number WO/2006/115140
Publication Date 02.11.2006
International Application No. PCT/JP2006/308185
International Filing Date 19.04.2006
IPC
A61K 45/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45Medicinal preparations containing active ingredients not provided for in groups A61K31/-A61K41/132
A61K 31/4439 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
44Non-condensed pyridines; Hydrogenated derivatives thereof
4427containing further heterocyclic ring systems
4439containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
A61P 1/04 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
04for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
A61P 1/12 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
12Antidiarrhoeals
C07D 401/12 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
CPC
A61K 31/4439
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
44Non condensed pyridines; Hydrogenated derivatives thereof
4427containing further heterocyclic ring systems
4439containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
A61P 1/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
A61P 1/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
04for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
A61P 1/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
12Antidiarrhoeals
C07D 401/12
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
C07D 409/12
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
409Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
Applicants
  • アステラス製薬株式会社 Astellas Pharma Inc. [JP]/[JP] (AllExceptUS)
  • 石川 淳 ISHIKAWA, Jun [JP]/[JP] (UsOnly)
  • 武沢 竜一 TAKEZAWA, Ryuichi [JP]/[JP] (UsOnly)
  • 増永 陽平 MASUNAGA, Youhei [JP]/[JP] (UsOnly)
Inventors
  • 石川 淳 ISHIKAWA, Jun
  • 武沢 竜一 TAKEZAWA, Ryuichi
  • 増永 陽平 MASUNAGA, Youhei
Agents
  • 森田 拓 MORITA, Hiroshi
Priority Data
2005-12471222.04.2005JP
2005-12471322.04.2005JP
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) PREVENTIVE OR REMEDY FOR BOWEL DISEASE
(FR) AGENT PROPHYLACTIQUE OU AGENT THERAPEUTIQUE CONTRE LA MALADIE ENTERIQUE
(JA) 腸疾患の予防若しくは治療剤
Abstract
(EN)
It is intended to provide a preventive or a remedy for inflammatory colitis, irritable bowel syndrome and various diarrhea caused by other factors. It was found for the first time that CRAC/SOC channel plays a physiologically important role in water secretion or absorption in gastrointestinal epithelial cells and a CRAC/SOC channel inhibitor is useful for preventing and treating diarrhea caused by various factors, and a preventive and a remedy for diarrhea comprising a compound inhibiting the calcium release activated calcium channel as an active ingredient, particularly a remedy for diarrheal symptoms associated with inflammatory bowel diseases and a remedy for irritable bowel syndrome are provided.
(FR)
L'invention concerne un agent prophylactique ou un agent thérapeutique contre la colite inflammatoire, le syndrome du côlon irritable et diverses diarrhées causées par d'autres facteurs. On a découvert pour la première fois que le canal CRAC/SOC joue un rôle physiologiquement important dans la sécrétion ou l'absorption d'eau dans les cellules épithéliales gastro-intestinales et qu'un inhibiteur du canal CRAC/SOC est utile pour prévenir et traiter la diarrhée causée par divers facteurs. L'invention concerne un agent prophylactique et un agent thérapeutique contre la diarrhée renfermant un composé inhibant le canal calcique activé par libération de calcium comme ingrédient actif, et notamment un agent thérapeutique contre les symptômes diarrhéiques associés aux maladies intestinales inflammatoires et un agent thérapeutique contre le syndrome du côlon irritable.
(JA)
 【課題】  炎症性大腸炎、過敏性腸症候群及びその他の要因で起こる各種下痢の予防・治療剤の提供。  【解決手段】 CRAC/SOCチャンネルが消化管上皮細胞において水分泌あるいは吸収において生理的に重要な役割を担っていること、並びにCRAC/SOCチャンネル阻害剤が種々の要因によって発生する下痢の予防並びに治療に有用であることを初めて知見し、カルシウム遊離活性型カルシウム・チャンネルを阻害する化合物を有効成分とする下痢の予防並びに治療剤、殊に、炎症性腸疾患に伴う下痢症状の治療剤並びに過敏性腸症候群治療剤を提供する。
Latest bibliographic data on file with the International Bureau