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1. (WO2006114739) METHOD FOR USING CEST CONTRAST AGENTS IN MRI
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/114739    International Application No.:    PCT/IB2006/051237
Publication Date: 02.11.2006 International Filing Date: 21.04.2006
IPC:
G01R 33/28 (2006.01), G01R 33/48 (2006.01)
Applicants: KONINKLIJKE PHILIPS ELECTRONICS N.V. [NL/NL]; Groenewoudseweg 1, NL-5621 BA Eindhoven (NL) (For All Designated States Except US).
WEGH, Rene, T. [NL/NL]; (NL) (For US Only).
PIKKEMAAT, Jeroen, A. [NL/NL]; (NL) (For US Only).
WILLARD, Nicolaas, P. [NL/NL]; (NL) (For US Only)
Inventors: WEGH, Rene, T.; (NL).
PIKKEMAAT, Jeroen, A.; (NL).
WILLARD, Nicolaas, P.; (NL)
Agent: COHEN, Julius, S.; Prof. Holstlaan 6, NL-5656 AA Eindhoven (NL)
Priority Data:
05103355.3 26.04.2005 EP
Title (EN) METHOD FOR USING CEST CONTRAST AGENTS IN MRI
(FR) UTILISATION D'AGENTS DE CONTRASTE CEST EN IRM
Abstract: front page image
(EN)The invention relates to a method for mapping of a physico-chemical parameter such as pH, temperature, pO2 or metabolite concentration using a chemical exchange saturation transfer contrast agent in Magnetic Resonance Imaging. This method is a modification of the known ratiometric method and may be used with agents having only one exchangeable entity pool, e.g. proton pool, by applying two different RF frequencies for pre-saturation of the contrast agent.
(FR)La présente invention concerne un procédé permettant de cartographier un paramètre physicochimique en utilisant un agent de contraste à transfert de saturation par échange chimique ou CEST (Chemical Exchange Saturation Transfer) en IRM. Ce procédé peut s'utiliser avec des agents ne disposant que d'un groupement d'entités échangeables tels que des groupements de protons, par application de deux fréquences RF différentes pour la pré-saturation de l'agent de contraste.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)