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1. (WO2006114704) P-CADHERIN ANTIBODIES

Pub. No.:    WO/2006/114704    International Application No.:    PCT/IB2006/001053
Publication Date: Nov 2, 2006 International Filing Date: Apr 13, 2006
IPC: C07K 16/28
A61K 39/395
Applicants: PFIZER INC.
BAUER, Christopher Todd
BOURNER, Maureen, Jeri
BOYLE, Melanie
CASPERSON, Gerald Fries
GRIGGS, David William
HEAD, Richard David
JOY, William Dean
MAZZARELLA, Richard Allen
MINTER, Ralph Raymond
MOFFAT, Mark Allen
THIELE, Barrett Richard
VANARSDALE, Todd Lee
Inventors: BAUER, Christopher Todd
BOURNER, Maureen, Jeri
BOYLE, Melanie
CASPERSON, Gerald Fries
GRIGGS, David William
HEAD, Richard David
JOY, William Dean
MAZZARELLA, Richard Allen
MINTER, Ralph Raymond
MOFFAT, Mark Allen
THIELE, Barrett Richard
VANARSDALE, Todd Lee
Title: P-CADHERIN ANTIBODIES
Abstract:
The present invention relates to antibodies including human antibodies and antigen- binding portions thereof that bind to P-cadherin, and that function to inhibit P-cadherin. The invention also relates to heavy and light chain immunoglobulins derived from human P- cadherin antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human P-cadherin antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions. The invention also relates to transgenic animals or plants comprising nucleic acid molecules of the present invention.