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1. (WO2006114467) USE OF HYDROXYTYROSOL IN THE PREVENTION AND TREATMENT OF CEREBRAL ISCHEMIC STROKE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/114467    International Application No.:    PCT/ES2006/000206
Publication Date: 02.11.2006 International Filing Date: 27.04.2006
IPC:
A61K 31/05 (2006.01), A61K 31/222 (2006.01), A61P 25/00 (2006.01)
Applicants: LABORATORIOS ALCALÁ FARMA, S.L. [ES/ES]; Carretera M-300, Km.29,920, E-28802 Alcalá de Henares (Madrid) (ES) (For All Designated States Except US).
DE LA CRUZ CORTÉS, José Pedro [ES/ES]; (ES) (For US Only).
GONZÁLEZ CORREA, José Antonio [ES/ES]; (ES) (For US Only).
SÁNCHEZ DE LA CUESTA Y ALARCÓN, Felipe [ES/ES]; (ES) (For US Only)
Inventors: DE LA CRUZ CORTÉS, José Pedro; (ES).
GONZÁLEZ CORREA, José Antonio; (ES).
SÁNCHEZ DE LA CUESTA Y ALARCÓN, Felipe; (ES)
Agent: GIL VEGA, Victor; Estébanez Calderón, 3, E-28020 Madrid (ES)
Priority Data:
P 200501022 27.04.2005 ES
Title (EN) USE OF HYDROXYTYROSOL IN THE PREVENTION AND TREATMENT OF CEREBRAL ISCHEMIC STROKE
(ES) USO DE HIDROXITIROSOL EN LA PREVENCIÓN Y TRATAMIENTO DEL ICTUS CEREBRAL ISQUÉMICO
(FR) UTILISATION D'HYDROXYTIRISOL DANS LA PREVENTION ET LE TRAITEMENT DE L'ICTUS CEREBRAL ISCHEMIQUE
Abstract: front page image
(EN)The invention relates to the use of hydroxytyrosol, an alcohol, an ester or a salt of same that is pharmaceutically acceptable for the preparation of a formulation for the prevention and treatment of cerebral ischemic stroke, said formulation producing effects in determined cerebral biochemical pathways, such as a reduction in tissue oxidative stress in the two aspects thereof, namely: inhibition of the oxidative damage (lipid peroxidation) and an increase in antioxidant defences (glutathione system); inhibition of inducible-type synthase nitric oxide activity and of nitric oxide tissue accumulation; and a reduction in prostaglandin E2 tissue accumulation.
(ES)La presente invención se refiere al uso de hidroxitirosol, una alcohol, un éster o una sal del mismo farmacéuticamente aceptable para Ia preparación de una formulación para Ia prevención y tratamiento del ictus cerebral isquémico, dicha formulación produce efectos en determinadas vías bioquímicas cerebrales, tales como reducción del estrés oxidativo tisular en sus dos vertientes: inhibición del daño oxidativo (peroxidación lipídica) e incremento de las defensas antioxidantes (sistema del glutatión); inhibición de Ia actividad óxido nítrico sintasa de tipo inducible y del acumulo tisular de óxido nítrico; y disminución del acumulo tisular de prostaglandina E2.
(FR)La présente invention porte sur l'utilisation d'hydroxytirisol sur un alcool, un ester ou son sel pharmaceutiquement acceptable pour la préparation d'une formulation afin d'éviter et de traiter l'ictus cérébral ischémique, laquelle formulation produit des effets dans des voies déterminées biochimiques cérébrales, notamment la réduction du stress oxydant tissulaire selon ses deux dimensions: inhibition de la lésion oxydante (peroxydation lipidique) et augmentation des défenses anti-oxydantes (système du glutation); inhibition de l'activité de l'oxyde nitrique syntase de type induisible et de l'accumulation tissulaire d'oxyde nitritique; et diminution de l'accumulation tissulaire de prostaglandine E2.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Spanish (ES)
Filing Language: Spanish (ES)