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1. (WO2006114275) ASSAY FOR CYTOCHROME P450 1A2

Pub. No.:    WO/2006/114275    International Application No.:    PCT/EP2006/003812
Publication Date: Nov 2, 2006 International Filing Date: Apr 21, 2006
IPC: G01N 33/60
Applicants: ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P ANGELETTI SPA
DI MARCO, Annalise
LAUFER, Ralph
Inventors: DI MARCO, Annalise
LAUFER, Ralph
Title: ASSAY FOR CYTOCHROME P450 1A2
Abstract:
A rapid and sensitive radiometric assay for assessing the activity of cytochrome P-450 (CYP) 1A2 and the potential of an analyte to inhibit CYP3A1A2 activity or induce CYP1A2 expression is described. All the steps of the assay, including incubations, product separation, and radioactivity counting are preferably performed in a multiwell format, which can be automated.