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1. WO2006113482 - ULTRAHIGH-RESOLUTION FIBER-OPTIC CONFOCAL MICROSCOPE AND METHOD OF USE

Publication Number WO/2006/113482
Publication Date 26.10.2006
International Application No. PCT/US2006/014162
International Filing Date 14.04.2006
IPC
G02B 21/00 2006.01
GPHYSICS
02OPTICS
BOPTICAL ELEMENTS, SYSTEMS, OR APPARATUS
21Microscopes
G02B 21/06 2006.01
GPHYSICS
02OPTICS
BOPTICAL ELEMENTS, SYSTEMS, OR APPARATUS
21Microscopes
06Means for illuminating specimen
CPC
G02B 21/0032
GPHYSICS
02OPTICS
BOPTICAL ELEMENTS, SYSTEMS, OR APPARATUS
21Microscopes
0004specially adapted for specific applications
002Scanning microscopes
0024Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
0032Optical details of illumination, e.g. light-sources, pinholes, beam splitters, slits, fibers
G02B 21/0084
GPHYSICS
02OPTICS
BOPTICAL ELEMENTS, SYSTEMS, OR APPARATUS
21Microscopes
0004specially adapted for specific applications
002Scanning microscopes
0024Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
008Details of detection or image processing, including general computer control
0084time-scale detection, e.g. strobed, ultra-fast, heterodyne detection
Applicants
  • THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTES OF HEALTH [US]/[US] (AllExceptUS)
  • ILEV, Ilko K. [BG]/[US] (UsOnly)
  • WAYNANT, Ronald W. [US]/[US] (UsOnly)
  • GANNOT, Israel [IL]/[US] (UsOnly)
  • GANDJBAKHCHE, Amir H. [US]/[US] (UsOnly)
Inventors
  • ILEV, Ilko K.
  • WAYNANT, Ronald W.
  • GANNOT, Israel
  • GANDJBAKHCHE, Amir H.
Agents
  • DALEY, Henry J.
Priority Data
60/671,10414.04.2005US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) ULTRAHIGH-RESOLUTION FIBER-OPTIC CONFOCAL MICROSCOPE AND METHOD OF USE
(FR) MICROSCOPE CONFOCAL A FIBRE OPTIQUE A RESOLUTION ULTRA-ELEVEE ET PROCEDE D'UTILISATION
Abstract
(EN)
An ultrahigh-resolution fiber-optic confocal microscope has an illumination system; three single-mode optical fibers, each optically coupled to a fiber coupler; a sample support stage arranged to receive illumination radiation from an end of one of the single-mode optical fibers; a detector arranged to receive output radiation from one of the single-mode optical fibers; and a lock-in amplifier electrically connected to the detector and the illumination system. The illumination system is adapted to provide illumination radiation that has a time-varying strength that is correlated with the detector by the lock-in amplifier.
(FR)
Selon l'invention, un microscope confocal à fibre optique à résolution ultra-élevée comprend un système d'éclairage; trois fibres optiques en mode simple dont chacune est couplée à un coupleur de fibres; un étage de support d'échantillon, conçu pour recevoir un rayonnement d'éclairage d'une extrémité d'une des fibres optiques en mode simple; un détecteur conçu pour recevoir un rayonnement de sortie provenant de l'une fibres optiques en mode simple; et un amplificateur de verrouillage connecté électriquement au détecteur et au système d'éclairage. Le système d'éclairage est conçu pour fournir un rayonnement d'éclairage qui possède une intensité variable dans le temps, corrélée avec le détecteur par l'amplificateur de verrouillage.
Also published as
Latest bibliographic data on file with the International Bureau