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1. (WO2006111858) BIS-(COUMARIN) COMPOUNDS WITH ANTI-INFLAMMATORY ACTIVITY
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2006/111858 International Application No.: PCT/IB2006/001259
Publication Date: 26.10.2006 International Filing Date: 13.01.2006
IPC:
C07D 311/56 (2006.01) ,C07D 493/12 (2006.01) ,C07D 405/14 (2006.01) ,C07D 407/14 (2006.01) ,C07D 409/14 (2006.01) ,A61P 29/00 (2006.01) ,A61P 11/06 (2006.01) ,A61K 31/37 (2006.01) ,C07D 493/14 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
311
Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
02
ortho- or peri-condensed with carbocyclic rings or ring systems
04
Benzo [b] pyrans, not hydrogenated in the carbocyclic ring
42
with oxygen or sulfur atoms in positions 2 and 4
56
without hydrogen atoms in position 3
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
493
Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
12
in which the condensed system contains three hetero rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
405
Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
14
containing three or more hetero rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
407
Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/183
14
containing three or more hetero rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
409
Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
14
containing three or more hetero rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29
Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11
Drugs for disorders of the respiratory system
06
Antiasthmatics
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
335
having oxygen as the only ring hetero atom, e.g. fungichromin
365
Lactones
366
having six-membered rings, e.g. delta-lactones
37
Coumarins, e.g. psoralen
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
493
Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
12
in which the condensed system contains three hetero rings
14
Ortho-condensed systems
Applicants:
MERCEP, Mladen [HR/HR]; HR (UsOnly)
MALNAR, Ivica [HR/HR]; HR (UsOnly)
HRVACIC, Boska [HR/HR]; HR (UsOnly)
MARKOVIC, Stribor [HR/HR]; HR (UsOnly)
FILIPOVIC SUCIC, Anita [HR/HR]; HR (UsOnly)
BOSNJAK, Berislav [HR/HR]; HR (UsOnly)
CEMPUH KLONKAY, Andreja [HR/HR]; HR (UsOnly)
RUPCIC, Renata [HR/HR]; HR (UsOnly)
HUTINEC, Antun [HR/HR]; HR (UsOnly)
ELENKOV, Ivaylo Jivkov [HR/HR]; HR (UsOnly)
MESIC, Milan [HR/HR]; HR (UsOnly)
GLAXOSMITHKLINE ISTRAZIVACKI CENTAR ZAGREB D.O.O. [HR/HR]; Prilaz Baruna Filipovica 29 10000 Zagrab, HR (AllExceptUS)
Inventors:
MERCEP, Mladen; HR
MALNAR, Ivica; HR
HRVACIC, Boska; HR
MARKOVIC, Stribor; HR
FILIPOVIC SUCIC, Anita; HR
BOSNJAK, Berislav; HR
CEMPUH KLONKAY, Andreja; HR
RUPCIC, Renata; HR
HUTINEC, Antun; HR
ELENKOV, Ivaylo Jivkov; HR
MESIC, Milan; HR
Priority Data:
60/644,35914.01.2005US
60/647,79327.01.2005US
Title (EN) BIS-(COUMARIN) COMPOUNDS WITH ANTI-INFLAMMATORY ACTIVITY
(FR) COMPOSES DE BIS-(COUMARINE) POSSEDANT UNE ACTIVITE ANTI-INFLAMMATOIRE
Abstract:
(EN) Certain bis-(coumarin) compounds of formula (VI) as well as the products of thei intramolecular cyclization including pharmaceutically acceptable salts, hydrates, solvates, clathrates, prodrugs, tautomers and stereoisomers thereof are disclosed. Certain processes and intermediates for the preparation of certain bis-(coumarin) compounds, as well as for the use of these compounds as therapeutically active agents in the prophylaxis and treatment of asthma and other inflammatory diseases and conditions in mammals, especially humans are also disclosed.
(FR) L'invention concerne certains composés de bis-(coumarine), ainsi que les produits de leur cyclisation intramoléculaire, y compris leurs sels acceptables sur le plan pharmaceutique, leurs hydrates, solvates, clathrates, promédicaments, tautomères et stéréoisomères. Elle concerne également certains processus et intermédiaires servant à préparer certains composés de bis-(coumarine) et l'utilisation de ces composés en tant qu'agents actifs sur le plan thérapeutique pour la prophylaxie et la thérapie de l'asthme ou d'autres maladies ou états inflammatoires chez les mammifères, en particulier, les humains.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)