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1. WO2006111858 - BIS-(COUMARIN) COMPOUNDS WITH ANTI-INFLAMMATORY ACTIVITY

Publication Number WO/2006/111858
Publication Date 26.10.2006
International Application No. PCT/IB2006/001259
International Filing Date 13.01.2006
IPC
C07D 311/56 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
311Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
02ortho- or peri-condensed with carbocyclic rings or ring systems
04Benzo pyrans, not hydrogenated in the carbocyclic ring
42with oxygen or sulfur atoms in positions 2 and 4
56without hydrogen atoms in position 3
C07D 493/12 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
493Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
12in which the condensed system contains three hetero rings
C07D 405/14 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
405Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
14containing three or more hetero rings
C07D 407/14 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
407Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/183
14containing three or more hetero rings
C07D 409/14 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
409Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
14containing three or more hetero rings
A61P 29/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)
CPC
A61K 47/545
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
54the modifying agent being an organic compound
545Heterocyclic compounds
A61P 1/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
A61P 1/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
04for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
A61P 11/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
A61P 11/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
02Nasal agents, e.g. decongestants
A61P 11/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
06Antiasthmatics
Applicants
  • GLAXOSMITHKLINE ISTRAZIVACKI CENTAR ZAGREB D.O.O. [HR]/[HR] (AllExceptUS)
  • MERCEP, Mladen [HR]/[HR] (UsOnly)
  • MALNAR, Ivica [HR]/[HR] (UsOnly)
  • HRVACIC, Boska [HR]/[HR] (UsOnly)
  • MARKOVIC, Stribor [HR]/[HR] (UsOnly)
  • FILIPOVIC SUCIC, Anita [HR]/[HR] (UsOnly)
  • BOSNJAK, Berislav [HR]/[HR] (UsOnly)
  • CEMPUH KLONKAY, Andreja [HR]/[HR] (UsOnly)
  • RUPCIC, Renata [HR]/[HR] (UsOnly)
  • HUTINEC, Antun [HR]/[HR] (UsOnly)
  • ELENKOV, Ivaylo Jivkov [HR]/[HR] (UsOnly)
  • MESIC, Milan [HR]/[HR] (UsOnly)
Inventors
  • MERCEP, Mladen
  • MALNAR, Ivica
  • HRVACIC, Boska
  • MARKOVIC, Stribor
  • FILIPOVIC SUCIC, Anita
  • BOSNJAK, Berislav
  • CEMPUH KLONKAY, Andreja
  • RUPCIC, Renata
  • HUTINEC, Antun
  • ELENKOV, Ivaylo Jivkov
  • MESIC, Milan
Priority Data
60/644,35914.01.2005US
60/647,79327.01.2005US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) BIS-(COUMARIN) COMPOUNDS WITH ANTI-INFLAMMATORY ACTIVITY
(FR) COMPOSES DE BIS-(COUMARINE) POSSEDANT UNE ACTIVITE ANTI-INFLAMMATOIRE
Abstract
(EN) Certain bis-(coumarin) compounds of formula (VI) as well as the products of thei intramolecular cyclization including pharmaceutically acceptable salts, hydrates, solvates, clathrates, prodrugs, tautomers and stereoisomers thereof are disclosed. Certain processes and intermediates for the preparation of certain bis-(coumarin) compounds, as well as for the use of these compounds as therapeutically active agents in the prophylaxis and treatment of asthma and other inflammatory diseases and conditions in mammals, especially humans are also disclosed.
(FR) L'invention concerne certains composés de bis-(coumarine), ainsi que les produits de leur cyclisation intramoléculaire, y compris leurs sels acceptables sur le plan pharmaceutique, leurs hydrates, solvates, clathrates, promédicaments, tautomères et stéréoisomères. Elle concerne également certains processus et intermédiaires servant à préparer certains composés de bis-(coumarine) et l'utilisation de ces composés en tant qu'agents actifs sur le plan thérapeutique pour la prophylaxie et la thérapie de l'asthme ou d'autres maladies ou états inflammatoires chez les mammifères, en particulier, les humains.
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