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1. WO2006109190 - TETRACYCLIC MONOAMINE REUPTAKE INHIBITORS FOR TREATMENT OF CNS DISEASES AND DISORDERS

Publication Number WO/2006/109190
Publication Date 19.10.2006
International Application No. PCT/IB2006/001480
International Filing Date 01.02.2006
IPC
C07D 495/04 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
495Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
A61K 31/55 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
55having seven-membered rings, e.g. azelastine, pentylenetetrazole
A61P 25/24 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
24Antidepressants
CPC
A61P 1/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
A61P 13/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13Drugs for disorders of the urinary system
02of urine or of the urinary tract, e.g. urine acidifiers
A61P 15/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
15Drugs for genital or sexual disorders
A61P 17/14
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
14for baldness or alopecia
A61P 21/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
21Drugs for disorders of the muscular or neuromuscular system
A61P 25/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
Applicants
  • GLAXOSMITHKLINE ISTRAZIVACKI CENTAR ZAGREB D.O.O. [HR]/[HR] (AllExceptUS)
  • MESIC, Milan [HR]/[HR] (UsOnly)
  • MERCEP, Mladen [HR]/[HR] (UsOnly)
  • PESIC, Dijana [HR]/[HR] (UsOnly)
  • RUPCIC, Renata [HR]/[HR] (UsOnly)
  • STANIC, Barbara [HR]/[HR] (UsOnly)
Inventors
  • MESIC, Milan
  • MERCEP, Mladen
  • PESIC, Dijana
  • RUPCIC, Renata
  • STANIC, Barbara
Priority Data
60/649,80702.02.2005US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) TETRACYCLIC MONOAMINE REUPTAKE INHIBITORS FOR TREATMENT OF CNS DISEASES AND DISORDERS
(FR) INHIBITEURS DE REABSORPTION DE MONOAMINES TETRACYCLIQUES POUR LE TRAITEMENT DE MALADIES ET TROUBLES DU SYSTEME NERVEUX CENTRAL
Abstract
(EN) Novel tetracyclic dibenzo (e,h) azulene compounds of formula (I); their pharmacologically acceptable derivatives; pharmaceutical compositions containing them and their activity and use in the treatment of central nervous system (CNS) diseases and conditions in humans and animals.
(FR) La présente invention a trait à de nouveaux composés tétracycliques à base de dibenzo(e,h)azulène, représentés pas la formule (I), à leurs dérivés pharmacologiquement acceptables, à des compositions pharmaceutiques les contenant et à leur activité et utilisation dans le traitement de maladies et conditions du système nerveux central (CNS) chez les humains et les animaux.
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