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1. (WO2006108276) A METHOD OF TREATING CANCER USING DICHLOROACETATE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2006/108276    International Application No.:    PCT/CA2006/000548
Publication Date: 19.10.2006 International Filing Date: 11.04.2006
IPC:
A61K 31/19 (2006.01), C12Q 1/00 (2006.01), A61P 35/00 (2006.01)
Applicants: THE GOVERNORS OF THE UNIVERSITY OF ALBERTA [CA/CA]; #4000 Research Transition Facility, 8308 - 114 Street, Edmonton, Alberta T6G 2E1 (CA) (For All Designated States Except US).
MICHELAKIS, Evangelos [CA/CA]; (CA) (For US Only).
ARCHER, Stephen [CA/CA]; (CA) (For US Only)
Inventors: MICHELAKIS, Evangelos; (CA).
ARCHER, Stephen; (CA)
Agent: NADOR, Anita; McCarthy Tétrault LLP, Box 48, Suite 4700, Toronto Dominion Bank Tower, Toronto, Ontario M5K 1E6 (CA)
Priority Data:
60/669,884 11.04.2005 US
Title (EN) A METHOD OF TREATING CANCER USING DICHLOROACETATE
(FR) PROCEDE DE TRAITEMENT ANTICANCEREUX PAR DICHLOROACETATE
Abstract: front page image
(EN)The invention relates to the use of dichloroacetate and chemical equivalents thereof for the treatment of cancer by inducing apoptosis or reversing apoptosis-resistance in a cell Preferably, the dosage is 10-100 mg/kg Preferably, sodium dichloroacetate is used. The dichloroacetate may optionally be given in combination with a pro-apoptotic agent and/or a chemotherapeutic agent Preferably, the cancers treated are non-small cell lung cancer, glioblastoma and breast carcinoma.
(FR)L'invention concerne l'utilisation de dichloroacétate et de ses équivalents chimiques dans le traitement du cancer par déclenchement de l'apoptose ou inversement de la résistance à l'apoptose dans une cellule. De préférence, le dosage est de 10-100 mg/kg. De préférence, du dichloroacétate de sodium est utilisé. Le dichloroacétate peut être éventuellement administré en combinaison avec un agent pro-apoptotique et/ou un agent chimiothérapeutique. De préférence, les types de cancer traités sont le cancer du poumon 'non à petites cellule', le glioblastome et le cancer du sein.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)