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1. (WO2006107853) PYRAZOLOPYRIDINE-1,4-DIAMINES AND ANALOGS THEREOF
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2006/107853 International Application No.: PCT/US2006/012265
Publication Date: 12.10.2006 International Filing Date: 31.03.2006
IPC:
C07D 471/04 (2006.01) ,C07D 487/04 (2006.01) ,A61K 31/437 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
471
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
487
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
4353
ortho- or peri-condensed with heterocyclic ring systems
437
the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
Applicants:
COLEY PHARMACEUTICAL GROUP, INC. [US/US]; 93 Worcester Street, Suite 101 Wellesley, Massachusetts 02481, US (AllExceptUS)
HAYS, David, S. [US/US]; US (UsOnly)
NIWAS, Shri [US/US]; US (UsOnly)
LUNDQUIST, Gregory, D., Jr. [US/US]; US (UsOnly)
Inventors:
HAYS, David, S.; US
NIWAS, Shri; US
LUNDQUIST, Gregory, D., Jr.; US
Agent:
GATES, Edward, R.; WOLF, GREENFIELD & SACKS, P.C. 600 Atlantic Avenue Boston, Massachusetts 02210-2206, US
Priority Data:
60/667,82801.04.2005US
Title (EN) PYRAZOLOPYRIDINE-1,4-DIAMINES AND ANALOGS THEREOF
(FR) PYRAZOLOPYRIDINE-1,4-DIAMINES ET ANALOGUES ASSOCIES
Abstract:
(EN) Pyrazolopyridine-1,4-diamines and analogs thereof, e.g., pyrazolo[3,4-c]pyridine-1,4-diamines, pyrazolo[3,4-c]quinoline-1,4-diamines, 6,7,8,9-tetrahydro pyrazolo[3,4-c]quinoline-1,4-diamines, and pyrazolo[3,4-c]naphthyridine-1,4-diamines, pharmaceutical compositions containing the compounds, intermediates, methods of making these compounds, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.
(FR) L'invention concerne des pyrazolopyridine-1,4-diamines et des analogues associés, par exemple, des pyrazolo[3,4-c]pyridine-1,4-diamines, des pyrazolo[3,4-c]quinoline-1,4-diamines, 6,7,8,9-tétrahydro pyrazolo[3,4-c]quinoline-1,4-diamines, et des pyrazolo[3,4-c]naphthyridine-1,4-diamines, des compositions pharmaceutiques renfermant lesdits composés, des intermédiaires, des méthodes d'élaboration desdits composés et des méthodes d'utilisation de ces composés en tant qu'immunomodulateurs pour l'induction de la biosynthèse de la cytokine chez des animaux et dans le traitement de maladies, y compris, des maladies virales et néoplasiques.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP1869043JP2008535832US20090124611CA2602683AU2006232377