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1. WO2006102574 - DETECTION OF GDF-8 MODULATING AGENTS

Publication Number WO/2006/102574
Publication Date 28.09.2006
International Application No. PCT/US2006/010723
International Filing Date 23.03.2006
IPC
G01N 33/68 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68involving proteins, peptides or amino acids
CPC
A61P 21/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
21Drugs for disorders of the muscular or neuromuscular system
A61P 43/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
G01N 2500/00
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2500Screening for compounds of potential therapeutic value
G01N 33/74
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
74involving hormones ; or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
Applicants
  • WYETH [US]/[US] (AllExceptUS)
  • NOWAK, John, A. [US]/[US] (UsOnly)
  • CRYAN, John, G. [US]/[US] (UsOnly)
  • MURRAY, Kristin, F. [US]/[US] (UsOnly)
  • RAJEWSKI, Joseph, W. [US]/[US] (UsOnly)
  • SUN, Shujun [US]/[US] (UsOnly)
  • WOLFMAN, Neil, M. [US]/[US] (UsOnly)
Inventors
  • NOWAK, John, A.
  • CRYAN, John, G.
  • MURRAY, Kristin, F.
  • RAJEWSKI, Joseph, W.
  • SUN, Shujun
  • WOLFMAN, Neil, M.
Agents
  • FERGUSON, Mary, K.
Priority Data
60/664,40023.03.2005US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) DETECTION OF GDF-8 MODULATING AGENTS
(FR) DETECTION D'AGENTS MODULATEURS DE GDF-8
Abstract
(EN)
Methods to detect GDF-8 modulating agents in animals, including humans, are provided herein, including methods to detect the presence of exogenous GDF-8 modulating agent such as a GDF-8 inhibitor in a biological sample. In particular, methods to assess the presence and/or quantity of a GDF-8 modulating agent in a biological sample are provided.
(FR)
L'invention concerne des méthodes permettant de détecter des agents modulateurs de GDF-8 chez des animaux, notamment des humains, notamment des méthodes permettant de détecter la présence d'un agent modulateur exogène de GDF-8, tel qu'un inhibiteur de GDF-8 dans un prélèvement biologique. D'une manière plus spécifique, l'invention concerne des méthodes permettant d'évaluer la présence et/ou la quantité d'agents modulateurs de GDF-8 dans un prélèvement biologique.
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