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1. WO2006102446 - MULTI-PARTICULATE, MODIFIED-RELEASED COLONIC COMPOSITION

Publication Number WO/2006/102446
Publication Date 28.09.2006
International Application No. PCT/US2006/010457
International Filing Date 20.03.2006
IPC
A61K 9/54 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
48Preparations in capsules, e.g. of gelatin, of chocolate
52Sustained or differential release type
54containing discrete particles with coatings of different thicknesses or different materials
A61K 9/26 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
20Pills, lozenges or tablets
22Sustained or differential release type
26Discrete particles in supporting matrix
A61K 31/606 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
60Salicylic acid; Derivatives thereof
606having amino groups
CPC
A61K 31/606
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
60Salicylic acid; Derivatives thereof
606having amino groups
A61K 9/2081
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
20Pills, tablets, ; discs, rods
2072characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
2077Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
2081with microcapsules or coated microparticles according to A61K9/50
A61K 9/5073
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
48Preparations in capsules, e.g. of gelatin, of chocolate
50Microcapsules ; having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
5073having two or more different coatings optionally including drug-containing subcoatings
Applicants
  • SANDOZ AG [CH]/[CH] (AllExceptUS)
  • PATEL, Ashish, Anilbhai [IN]/[US] (UsOnly)
  • PALANIWAMY, Suresh [US]/[US] (UsOnly)
  • DAVILA, Pablo [US]/[ES] (UsOnly)
Inventors
  • PATEL, Ashish, Anilbhai
  • PALANIWAMY, Suresh
  • DAVILA, Pablo
Agents
  • THALLEMER, John, D.
Priority Data
11/085,67121.03.2005US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) MULTI-PARTICULATE, MODIFIED-RELEASED COLONIC COMPOSITION
(FR) COMPOSITION MULTIPARTICULAIRE A LIBERATION MODIFIEE
Abstract
(EN)
A multi-particulate, modified-release pharmaceutical composition for the oral administration of an active ingredient to the colon, wherein said particles comprise: (a) a core comprising an active ingredient or a pharmaceutically acceptable salt or ester thereof, and optionally one or more excipients; (b) a first coating applied to the surface of the core, wherein said first coating is insoluble in gastric juice and in intestinal juice below pH 7, but soluble in colonic intestinal juice; and (c) a second coating applied to the surface of the first coating.
(FR)
L'invention concerne une composition pharmaceutique multiparticulaire à libération modifiée destinée à l'administration par voie orale d'un principe actif au côlon, dans laquelle lesdites particules contiennent: (a) un coeur comprenant un principe actif ou un sel ou ester pharmaceutiquement acceptable de celui-ci et facultativement un ou plusieurs excipients; (b) un premier enrobage appliqué à la surface du coeur, ledit premier enrobage est insoluble dans le suc gastrique et dans le suc intestinal sous un pH 7, mais soluble dans le suc intestinal du côlon; et (c) un second enrobage appliqué à la surface du premier enrobage.
Also published as
EP6739307
Latest bibliographic data on file with the International Bureau