Processing

Please wait...

Settings

Settings

Goto Application

1. WO2006101922 - MEDICINAL COMPOSITIONS OF SALTS, CHELATES AND/OR FREE ACIDS OF ALPHA HYDROXYL ORGANIC ACIDS AND RELATED PROCESSES AND METHODS

Publication Number WO/2006/101922
Publication Date 28.09.2006
International Application No. PCT/US2006/009394
International Filing Date 16.03.2006
IPC
A61K 31/122 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
12Ketones
122having the oxygen atom directly attached to a ring, e.g. quinones, vitamin K1, anthralin
C12P 19/48 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
19Preparation of compounds containing saccharide radicals
44Preparation of O-glycosides, e.g. glucosides
46having an oxygen atom of the saccharide radical bound to a cyclohexyl radical, e.g. kasugamycin
48the cyclohexyl radical being substituted by two or more nitrogen atoms, e.g. destomycin, neamin
C12Q 1/68 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
CPC
A61K 31/19
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic, hydroximic acids
19Carboxylic acids, e.g. valproic acid
A61K 36/38
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
36Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
18Magnoliophyta (angiosperms)
185Magnoliopsida (dicotyledons)
38Clusiaceae, Hypericaceae or Guttiferae (Hypericum or Mangosteen family), e.g. common St. Johnswort
A61K 36/45
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
36Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
18Magnoliophyta (angiosperms)
185Magnoliopsida (dicotyledons)
45Ericaceae or Vacciniaceae (Heath or Blueberry family), e.g. blueberry, cranberry or bilberry
A61K 36/74
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
36Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
18Magnoliophyta (angiosperms)
185Magnoliopsida (dicotyledons)
74Rubiaceae (Madder family)
A61P 29/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29Non-central analgesic, antipyretic or anti-inflammatory agents, e.g antirheumatic agents; Non-steroidal anti-inflammatory drugs (NSAIDs)
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
Applicants
  • PERO, Ronald, W. [US]/[SE]
Inventors
  • PERO, Ronald, W.
Agents
  • HIGGINS, Patrick, H.
Priority Data
60/662,44616.03.2005US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) MEDICINAL COMPOSITIONS OF SALTS, CHELATES AND/OR FREE ACIDS OF ALPHA HYDROXYL ORGANIC ACIDS AND RELATED PROCESSES AND METHODS
(FR) COMPOSITIONS MEDICINALES DE SELS, CHELATES ET/OU ACIDES LIBRES D'ACIDES ORGANIQUES ALPHA HYDROXYLE ET PROCESSUS ET PROCEDES ASSOCIES
Abstract
(EN)
Processes are described for the production of an isolated medicinal composition for administration to mammals which comprises an effective amount of a free acid, salt or chelate of at least one naturally occurring form of an alpha hydroxyl organic acid comprising combining at least one naturally occurring form of an alpha hydroxy organic acid with an amount of base in an aqueous solution, wherein a total content of alpha hydroxyl organic acids amounts to between about 0.5% and about 35% w/w of the solution, for a time to hydrolyse substantially all forms of alpha hydroxyl organic acids present, neutralizing the solution to a pH between about 6.9 and about 7.6 to yield a free acid, salt or chelate of free acids of substantially all naturally occurring forms of alpha hydroxyl organic acids, and optionally lyophilizing the solution to produce an isolated medicinal composition. Compositions produced by these processes are disclosed and claimed. Method are described of enhancing DNA repair, enhancing an immune response, controlling inflammation, or inhibiting the progress of a tumor, comprising administering an effective amount of a composition produced by the processes described herein.
(FR)
Cette invention concerne des processus de production d'une composition médicinale isolée destinée à être administrée à des mammifères et comprenant une quantité efficace d'un acide libre, d'un sel ou d'un chélate d'au moins une forme naturelle d'un acide organique alpha hydroxyle, lesquels processus consistent à combiner au moins une forme naturelle d'un acide organique alpha hydroxyle à une quantité de base dans une solution aqueuse, une teneur totale en acides organiques alpha hydroxyle représentant entre environ 0,5 % et environ 35 % en poids de la solution, pendant une durée permettant d'hydrolyser substantiellement toutes les formes d'acides organiques alpha hydroxyle présentes, à neutraliser la solution à un pH compris entre environ 6,9 et environ 7,6 pour produire un acide libre, un sel ou un chélate d'acides libres de substantiellement toutes les formes naturelles d'acides organiques alpha hydroxyle et éventuellement à lyophiliser la solution pour produire une composition médicinale isolée. Cette invention concerne également les compositions produites par ces processus. Des procédés sont utilisés pour renforcer la réparation d'ADN, renforcer une réponse immunitaire, maîtriser une inflammation ou inhiber la progression d'une tumeur, lesquels procédés consistent à administrer une quantité efficace d'une composition produite par les processus ci-décrits.
Also published as
NO20075206
RU2007138220
Latest bibliographic data on file with the International Bureau