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1. WO2006101859 - PIPERIDINYL SUBSTITUTED CYCLOHEXANE-1,4-DIAMINES

Publication Number WO/2006/101859
Publication Date 28.09.2006
International Application No. PCT/US2006/009192
International Filing Date 15.03.2006
IPC
A61K 31/445 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
44Non-condensed pyridines; Hydrogenated derivatives thereof
445Non-condensed piperidines, e.g. piperocaine
C07D 221/26 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
221Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/-C07D219/187
02condensed with carbocyclic rings or ring systems
22Bridged ring systems
26Benzomorphans
CPC
A61P 13/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13Drugs for disorders of the urinary system
02of urine or of the urinary tract, e.g. urine acidifiers
A61P 13/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13Drugs for disorders of the urinary system
08of the prostate
A61P 43/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
C07D 211/14
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
211Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
04with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
06having no double bonds between ring members or between ring members and non-ring members
08with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
10with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
14with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
C07D 211/22
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
211Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
04with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
06having no double bonds between ring members or between ring members and non-ring members
08with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
18with substituted hydrocarbon radicals attached to ring carbon atoms
20with hydrocarbon radicals, substituted by singly bound oxygen or sulfur atoms
22by oxygen atoms
C07D 405/12
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
405Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
Applicants
  • JANSSEN PHARMACEUTICA, N.V. [BE]/[BE] (AllExceptUS)
  • CHIU, George [US]/[US] (UsOnly)
  • LI, Shengjian [CN]/[US] (UsOnly)
  • CONNOLLY, Peter, J. [US]/[US] (UsOnly)
  • PULITO, Virginia, L. [US]/[US] (UsOnly)
  • LIU, Jingchun [US]/[US] (UsOnly)
  • MIDDLETON, Steven, A. [US]/[US] (UsOnly)
Inventors
  • CHIU, George
  • LI, Shengjian
  • CONNOLLY, Peter, J.
  • PULITO, Virginia, L.
  • LIU, Jingchun
  • MIDDLETON, Steven, A.
Agents
  • JOHNSON, Philip, S.
Priority Data
60/664,30222.03.2005US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) PIPERIDINYL SUBSTITUTED CYCLOHEXANE-1,4-DIAMINES
(FR) CYCLOHEXANE-1,4-DIAMINES A SUBSTITUTION PIPERIDINYLE
Abstract
(EN)
The present invention relates to piperidine substituted cyclohexane-1,4-diamine compounds of Formula (I) and pharmaceutically acceptable forms thereof, as a1a/a1d adrenoreceptor modulators for the treatment of benign prostatic hypertrophy and lower urinary tract symptoms. The present invention also relates to pharmaceutical compositions comprising said new compounds, new processes to prepare these new compounds and new uses as a medicine as well as method of treatments.
(FR)
L'invention concerne des composés de cyclohexane-1,4-diamine à substitution pipéridine représentés par la formule (I) et des formes de ceux-ci pharmaceutiquement acceptables, utilisés comme modulateurs d'adrénorécepteur a1a/a1d pour traiter des symptômes d'hypertrophie bénigne de la prostate et de maladies des voies urinaires inférieures. L'invention concerne également des compositions pharmaceutiques comprenant les nouveaux composés, de nouveaux procédés de préparation de ces composés, de nouvelles méthodes d'utilisation comme médicament ainsi que des méthodes de traitement.
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