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1. WO2006101439 - SCREEN

Publication Number WO/2006/101439
Publication Date 28.09.2006
International Application No. PCT/SE2006/000355
International Filing Date 22.03.2006
IPC
G01N 33/68 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68involving proteins, peptides or amino acids
CPC
G01N 2333/726
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2333Assays involving biological materials from specific organisms or of a specific nature
435from animals; from humans
705Assays involving receptors, cell surface antigens or cell surface determinants
72for hormones
726G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH
G01N 2500/04
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2500Screening for compounds of potential therapeutic value
04Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
G01N 33/74
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
74involving hormones ; or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
Applicants
  • ASTRAZENECA AB [SE]/[SE] (AllExceptUS)
  • GRAHAMES, Caroline [GB]/[GB] (UsOnly)
  • MALLINDER, Philip [GB]/[GB] (UsOnly)
  • MCINTOSH, Fraser [GB]/[GB] (UsOnly)
  • TOMKINSON, Nicholas [GB]/[GB] (UsOnly)
  • WRIGHT, Tracey [GB]/[GB] (UsOnly)
Inventors
  • GRAHAMES, Caroline
  • MALLINDER, Philip
  • MCINTOSH, Fraser
  • TOMKINSON, Nicholas
  • WRIGHT, Tracey
Agents
  • ASTRAZENECA
Priority Data
0500668-923.03.2005SE
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) SCREEN
(FR) CRIBLAGE
Abstract
(EN)
The present invention relates to G protein-coupled receptors (GPCRs) and allosteric modulators thereof. More specifically, the invention relates to allosteric modulators of GPCRs that interact at an intracellular binding site. It also relates to methods for designing or identifying small molecule allosteric modulators, including assays (such as competitive binding assays) and methods employing a homology model for the GPCR intracellular site.
(FR)
L'invention concerne des récepteurs couplés aux protéines G (GPCR) et leurs modulateurs allostériques. En particulier, l'invention concerne des modulateurs allostériques de GPCR interagissant au niveau d'un site de liaison intracellulaire. L'invention concerne également des méthodes pour concevoir ou pour identifier de petits modulateurs allostériques moléculaires, comprenant des épreuves biologiques (notamment des épreuves biologiques de liaison de compétition) et des méthodes faisant appel à un modèle d'homologie pour le site intracellulaire GPCR.
Also published as
Latest bibliographic data on file with the International Bureau