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1. WO2006100439 - PHOSPHORAMIDATE DERIVATIVES OF NUCLEOSIDE COMPOUNDS FOR USE IN THE TREATMENT OF CANCER

Publication Number WO/2006/100439
Publication Date 28.09.2006
International Application No. PCT/GB2006/000932
International Filing Date 16.03.2006
IPC
C07H 19/20 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
19Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro derivatives thereof
02sharing nitrogen
04Heterocyclic radicals containing only nitrogen as ring hetero atom
16Purine radicals
20with the saccharide radical being esterified by phosphoric or polyphosphoric acids
A61P 35/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 35/02 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
02specific for leukemia
A61K 31/7076 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7042Compounds having saccharide radicals and heterocyclic rings
7052having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
706containing six-membered rings with nitrogen as a ring hetero atom
7064containing condensed or non-condensed pyrimidines
7076containing purines, e.g. adenosine, adenylic acid
CPC
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 35/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
02specific for leukemia
C07H 19/20
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
19Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides ; Anhydro-derivatives thereof
02sharing nitrogen
04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
16Purine radicals
20with the saccharide radical esterified by phosphoric or polyphosphoric acids
Applicants
  • UNIVERSITY COLLEGE CARDIFF CONSULTANTS LIMITED [GB]/[GB] (AllExceptUS)
  • MCGUIGAN, Christopher [GB]/[GB] (UsOnly)
  • MILLS, Kenneth [US]/[US] (UsOnly)
  • CONGIATU, Costantino [IT]/[IT] (UsOnly)
Inventors
  • MCGUIGAN, Christopher
  • MILLS, Kenneth
  • CONGIATU, Costantino
Agents
  • HOWARD, Paul, Nicholas
Priority Data
0505781.521.03.2005GB
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) PHOSPHORAMIDATE DERIVATIVES OF NUCLEOSIDE COMPOUNDS FOR USE IN THE TREATMENT OF CANCER
(FR) DERIVES DE PHOSPHORAMIDATE DE COMPOSES DE NUCLEOSIDE POUR TRAITER LE CANCER
Abstract
(EN)
Phosphoramidate derivatives of nucleoside compounds such as cladribine, isocladribine, fludaribine and clofarabine have enhanced therapeutic potency in homo sapiens, in particular, enhanced potency with respect to a cancer such as leukaemia. Suitably the phosphoramidate is substituted at the P atom by Ar-O, where Ar is aryl or heteroaryl, either of which may be optionally substituted. Formula (I).
(FR)
La présente invention concerne des dérivés de phosphoramidate de composés de nucléoside, tels que la cladribine, l'isocladribine, la fludaribine et la clofarabine qui ont un pouvoir thérapeutique amélioré chez l'homo sapiens, plus particulièrement en ce qui concerne le cancer, tel que la leucémie. Par ailleurs, le phosphoramidate est substitué au niveau de l'atome P par Ar-O, où Ar désigne un aryle ou un hétéroaryl, l'un ou l'autre pouvant être éventuellement substitué. (I).
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